Suberic Acid

Optimal Result: 0.7 - 9.3 nmol/mg Creatinine.

- Suberic acid is present in the urine of patients with fatty acid oxidation disorders.

- A metabolic breakdown product derived from oleic acid.

- Elevated levels of this unsaturated dicarboxylic acid are found in individuals with medium-chain acyl-CoA dehydrogenase deficiency (MCAD).

- Elevated in Schizophrenics

- People with metabolic syndrome or diabetes had significantly elevated adipic acid, suberic acid, lactic acid, and fumaric acid.

- Ketosis is sometimes accompanied by excessive excretion of adipic and suberic acid.

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Suberic Acid, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.

What is carnitine?

Carnitine is a nutrient necessary for moving fatty acids into the mitochondria where they are converted to energy using vitamin B2. When insufficient levels of carnitine or vitamin B2 slow down this process, other parts of the cellular machinery take over and make adipate and suberate.

A similar block in another pathway may cause high ethylmalonate. Since much of your body’s energy is produced from the burning of fatty acids, your muscles and brain suffer when this cellular energy pathway is blocked. Vitamin B2 insufficiency can underlie impaired carbohydrate metabolism, migraines and dementia. Research has shown carnitine supplementation may improve Alzheimer’s and age-related cognitive decline.

Anything that interferes with the normal fatty acid oxidation may reveal high levels of these metabolites. Rule out environmental toxin exposure, excessive aspirin use.

What does it mean if your Suberic Acid result is too high?

Adipate, Suberic Acid, and Ethylmalonate elevations indicate metabolic blocks. Carnitine is needed to move fatty acids into the mitochondria where they are converted to energy using vitamin B2 (riboflavin). When insufficient levels of carnitine or vitamin B2 (riboflavin) slow down this process, other parts of the cellular machinery take over and make adipate and suberate. A similar block in another pathway causes high ethylmalonate. Since most of your body’s energy is produced from the burning of fatty acids, your muscles and brain suffer when this cellular energy pathway is blocked. Supplementation of carnitine and vitamin B2 may be needed when these compounds are too high. Insufficiency of vitamin B2 is implicated in impaired carbohydrate metabolism, migraines, and dementia. Carnitine supplementation has been documented to improve Alzheimer’s, age-related cognitive decline, and cardiac function.

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