Xanthurenic Acid

Optimal Result: 0.6 - 10.2 nmol/mg Creatinine.

OMX Organic Metabolomics / Diagnostic Solutions Diagnostic Solutions Laboratory | GI-MAP & Food Sensitivity Tests

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Lab Results Explained and Tracked

(Xanthurenate)

From the breakdown of hydroxykynurenine via kynurenine aminotransferases (KAT) +B6

- Elevated xanthurenic acid has been noted with B6 deficiency.

- Elevated levels have been noted as more significant in oral contraceptive users in studies using a tryptophan load.

- In a mathematical model without a tryptophan load, a moderate vitamin B6 deficiency resulted in a slight increase in xanthurenic acid and a slight decrease in kynurenic acid and anthranilate.

- Without a tryptophan load, urine kynurenine and xanthurenic acid both increase in a pronounced B6 deficiency.

- Animal studies found a low urinary excretion ratio of xanthurenic acid/ kynurenic acid as a possible marker of niacin need, proposing that levels may increase with repletion.

- Niacin (vitamin B3) is a product of tryptophan degradation. In alcoholic pellagra patients, the tryptophanniacin pathway is inhibited after the 3-hydroxyanthranilate oxidase step, which can result in increased kynurenic acid, and decreased xanthurenic acid and quinolinic acid.

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What does it mean if your Xanthurenic Acid result is too high?

Because this pathway is heavily dependent on vitamin B6, elevations of xanthurenic acid can reflect a functional need for vitamin B6.

Kynurenine pathway metabolites may also become elevated when there are needs for vitamin B3.

Elevations in urinary xanthurenic acid are seen with increased intake of tryptophan, and in high estrogen states. Pregnancy and oral contraceptive use is associated with elevated levels of urinary xanthurenic acid where a functional nutrient need for B-vitamins is pronounced.

Abnormalities in the kynurenine pathway have been associated with many clinical conditions including immune suppression, cancer, and inflammatory conditions. Administration of vitamin B6 can decrease xanthurenic acid excretion.

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Xanthurenic Acid

All Your Lab Results. One Simple Dashboard.

What does it mean if your Xanthurenic Acid result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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