Picolinic Acid

Optimal Result: 0 - 4 nmol/mg Creatinine.

Other names: Picolinate

From the breakdown of hydroxykynurenine via ACMS decarboxylase

- Decreased picolinic acid and increased quinolinic acid blood levels noted in suicidal subjects.

- A tryptophan metabolite produced through non-enzymatic conversion.

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Picolinate is a neurotransmitter metabolism marker and is produced under inflammatory conditions.

Picolinate is a catabolite of the amino acid tryptophan through the kynurenine pathway [1].

Its function is unclear, but it has been implicated in a variety neuro-protective, immunological, and anti-proliferative affects [3]. In addition, it is suggested to assist in the absorption of zinc ions and other divalent or trivalent ions through the small intestine.

Neurotransmitters are the chemicals your nervous system uses to function and communicate with your body. Abnormalities in this area can relate to symptoms of mental, emotional, and behavioral problems.

Nutrient Associations:

- Antioxidants (Vit C, Vit E, Lipoic acid)

- Omega 3 fatty acids,

References:

https://www.nature.com/articles/tp2016133/figures/1

http://www.jimmunol.org/content/164/6/3283

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195224

- https://pdfs.semanticscholar.org/3ce0/a6940a61dbde1379e0d80f87f708215c5802.pdf?_ga=2.77906132.1988772573.1550078220-1008387674.1550078220

https://www.sciencedaily.com/releases/2016/08/160809185857.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022080/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022080/

What does it mean if your Picolinic Acid result is too low?

Low Picolinate levels can be caused by excessively high fish oil intake. 

Abnormalities in this area can relate to symptoms of mental, emotional, and behavioral problems, especially if quinolinic acid is increased. [L, L]

What does it mean if your Picolinic Acid result is too high?

Picolinate elevations can be caused by inflammatory processes induced by the immune system [2]. High protein diets can increase production of picolinate whereas polyunsaturated fatty acids divert the flow through the kynurenin pathway to quinolinate. In cases of elevated urinary picolinate, supplemental mineral-picolinate salts may be contributing sources.

Treatment considerations:

- Decrease protein diet
- Add Omega 3's (algae based)

Nutrient associations:

- Antioxidants (Vit C, Vit E, Lipoic acid)
- Omega 3
- Fatty acids

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