- Hydroxyproline is the key factor in stabilizing collagens.
- Hydroxyproline is abundant in meat and low in plant-based foods. Meat intake increases levels of proline and hydroxyproline.
- Increased hydroxyproline has been found in collagen catabolism (bone resorption, increased reactive oxygen species [ROS]), tissue degradation, muscle damage, or other conditions such as Paget's disease or Alzheimer's disease.
- Proline and hydroxyproline both negatively correlated with a higher likelihood of anxiety, depression, and psychoses.
Hydroxyproline
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