OMX Organic Metabolomics / Diagnostic Solutions

8-Hydroxy-2'-deoxyguanosine

Optimal Result: 0 - 6.4 nmol/mg Creatinine.

8-hydroxy-2-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.

8-hydroxy-2-deoxyguanosine is a non-invasive marker of cell damage. Some cell damage is a normal part of metabolism, but it is kept to a minimum by the cell’s protective mechanisms. Under certain circumstances, the balance between the damaging chemicals and protective mechanisms can be upset, resulting in a condition termed “oxidative stress.” Although numerous cell damage products can be formed, the one most often studied is 8-OHdG. When oxidative damage occurs to the cells, repair mechanisms produce 8-OHdG, which is excreted unchanged in the urine. High levels reflect high oxidative stress to the cells.a

What does it mean if your 8-Hydroxy-2'-deoxyguanosine result is too high?

Consider supplementing with Vitamin C, E, lipoic acid and NAC. Also consider using green tea, grapes and berries. Although an increase consumption of alcohol will have a detrimental impact on this marker, an occasional glass of red wine may be of value due to its high level of flavonoids.

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