a-Keto-b-methylvaleric Acid

Optimal Result: 0 - 83.5 nmol/mg Creatinine.

a-Keto-b-Methylvaleric Acid is a B-Complex Vitamin Marker. Vitamins are compounds that your body needs to be healthy. Vitamins are “essential” for proper function, which means that they are not made inside your body and must be consumed in the diet. The B-complex vitamins are necessary for many enzymes in your body to function properly. Your body uses enzymes to extract energy from food, to build new tissue, to remove toxins, and to maintain the immune system. The branched-chain amino acids are broken down to form α-ketoisovalerateα-ketoisocaproate, and α-keto-β-methylvalerate.

A dehydrogensase enzyme is needed for this step. Vitamins B1 , B2 , B3 , B5 , and lipoic acid are needed for this dehydrogenase to function properly. If these nutrients are insufficient, the keto acids may build up in the urine.

References:

http://ctdbase.org/detail.go?type=chem&acc=C016211

https://www.gdx.net/uk/core-uk/interpretive-guides-uk/Organix-IG.pdf

http://www.oxfordreference.com/view/10.1093/oi/authority.20110803095405411

What does it mean if your a-Keto-b-methylvaleric Acid result is too high?

a-Keto-b-Methylvaleric Acid comes from the essential amino acid isoleucine via transamination. Moderate elevations of a-Keto-b-Methylvaleric Acid usually mean that a-Keto-b-Methylvaleric Acid's further metabolism to the compound, alpha-methylbutyryl-CoA, is impaired either by coenzyme/cofactor insufficiency or by (genetic) weakness in the enzyme complex. 

The dehydrogenase enzyme complex that accomplishes this requires lipoic acid, vitamin B1 as thiamin pyrophosphate and vitamin B2 as FAD. Vitamin B3 as NAD is a necessary cofactor, which removes hydrogen to become NADH. The other necessary cofactor is coenzyme A, requiring pantothenic acid, cysteine, and magnesium.

Elevated levels of a-Keto-b-Methylvaleric Acid may indicate low levels of any of these nutrients. The toxic elements arsenic, antimony, mercury and cadmium may also weaken lipoic acid and dehydrogenase activity. 

Very high elevation of AKBM and its sister keto acids (alpha-ketoisovaleric, alpha-ketoisocaproic) constitute a rare disorder called "maple syrup urine disease". 

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Trust us to examine your lab results, guiding you towards improved health.

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.