Homovanillate (aka Homovanillic Acid) is a dopamine metabolite.
Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
When these compounds are low, it indicates your body is not making enough of these neurotransmitters. Low Homovanillate indicates low levels of dopamine. Symptoms associated with this condition are depression, sleep disturbances, inability to deal with stress, and fatigue.
- Low precursors/neurotransmitters (phenylalanine, dopamine, noradrenalin)
- Low cofactors (B2, B3, B6, Mg or Fe)
- Impaired methylation
- Vitamins & Minerals Analysis
Treatments to improve digestion, along with supplementation of tyrosine or phenylalanine, can help improve the ability to keep up with demand for these neurotransmitters.
- L-tyrosine & B6
- B2, B3 or Fe if low
- Support methylation (methionine/SAMe, B6, B12, folate, Mg)
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Elevations of Homovanillate and Vanilmandelate indicate an over-activation of nervous system function involving these neurotransmitters. This can be for various reasons, but is most commonly associated with stress, both internal (e.g., mental/emotional) and external (e.g., environmental toxins). Addressing the source of stress and improving the body’s ability to handle stress are useful in these cases.
- Increased catecholamine activity/stress pattern
- Impaired production of noradrenalin from dopamine
- Adrenal Hormone Profile
- Adrenal support
- Stress management
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2-Methylhippurate, 3,4-Dihydroxyphenylpropionate, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, Adipate, Alpha-Hydroxybutyrate, Alpha-Keto-Beta-Methylvalerate, Alpha-Ketoglutarate, Alpha-Ketoisocaproate, Alpha-Ketoisovalerate, Benzoate, Beta-Hydroxybutyrate, Beta-Hydroxyisovalerate, cis-Aconitate, Citrate, D-Arabinitol, D-Lactate, Ethylmalonate, Formiminoglutamate, Fumarate, Glucarate, Hippurate, Histamine, Homovanillate (Genova), Hydroxymethylglutarate, Indican, Isocitrate, Ketoisovalerate, Kynurenate, L-Lactate, Malate, Methylmalonate (Genova), Orotate, p-Hydroxybenzoate, p-Hydroxyphenylacetate, p-Hydroxyphenyllactate, Phenylacetate, Phenylpropionate, Picolinate, Pyroglutamate (Genova), Pyruvate (Genova), Quinolinic acid (Quinolinate) (Genova), Suberate, Succinate, Sulfate, Tricarballylate, Vanilmandelate (Genova), Xanthurenate (Genova)