A healthy result should fall into the range 0 - 11.5 mcg/mg creatinine.

Beta-Hydroxyisovalerate is a sensitive indicator of biotin deficiency and is a metabolite of the amino acid isoleucine.

Until recently, biotin deficiency was very difficult to determine in humans because this vitamin deficiency affects health in ways that mimic many other conditions. Doctors were likely to overlook biotin deficiency until this test was discovered.

Beta-Hydroxyisovalerate result calculator

insert the value from you Beta-Hydroxyisovalerate test result.

What does it mean if your Beta-Hydroxyisovalerate result is too high?

Beta-Hydroxyisovalerate is a specific and sensitive metabolic marker for functional biotin deficiency. As your biotin intake decreases, your beta-hydroxyisovalerate excretion increases. Biotin deficiencies develop for a number of reasons, including pregnancyantibiotic usedysbiosis (microbial imbalance) and anticonvulsant therapy (treatment of neuropathic pain.

It is important to remember that raw egg whites are rich in the glycoprotein, avidin which binds with biotin leading to a deficiency.


Symptoms can include:

  • hair loss
  • skin rash
  • dermatitis
  • immune deficiencies
  • gait disturbances
  • tremor
  • muscle weakness

Possible treatment:

  • Consider supplementing with biotin. Include biotin rich foods such as legumes, cruciferous vegetables and sweet potatoes.
  • Address dysbiosis.

Upload Full Test and Learn More

To learn more, visualize and track your test results, create a personal account.

Sign Up, Upload Tests, Get Insights and Improve with HealthMatters.io.

Sign up now.

Are you concerned about your blood test results?
Then get your personal health dashboard.


Personal Plan +

Unlimited Tests Upload Subscription
Cancel anytime

Sign Up


Personal Plan Basic

Single test upload.
Pay for each test result upload.

Upload Now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.