8-hydroxy-2-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.
8-hydroxy-2-deoxyguanosine is a non-invasive marker of cell damage. Some cell damage is a normal part of metabolism, but it is kept to a minimum by the cell’s protective mechanisms. Under certain circumstances, the balance between the damaging chemicals and protective mechanisms can be upset, resulting in a condition termed “oxidative stress.” Although numerous cell damage products can be formed, the one most often studied is 8-OHdG. When oxidative damage occurs to the cells, repair mechanisms produce 8-OHdG, which is excreted unchanged in the urine. High levels reflect high oxidative stress to the cells.a
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Consider supplementing with Vitamin C, E, lipoic acid and NAC. Also consider using green tea, grapes and berries. Although an increase consumption of alcohol will have a detrimental impact on this marker, an occasional glass of red wine may be of value due to its high level of flavonoids.
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2-Methylhippurate, 3,4-Dihydroxyphenylpropionate, 3-Hydroxybutyric acid, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, Adipate, Alpha-Hydroxybutyrate, Alpha-Keto-Beta-Methylvalerate, Alpha-Ketoglutarate, Alpha-Ketoisocaproate, Alpha-Ketoisovalerate, Benzoate, Beta-Hydroxybutyrate, Beta-Hydroxyisovalerate, cis-Aconitate, Citrate, D-Arabinitol, D-Lactate, Ethylmalonate, Formiminoglutamate, Fumarate, Glucarate, Hippurate, Histamine, Homovanillate (Genova), Hydroxymethylglutarate, Indican, Isocitrate, Ketoisovalerate, Kynurenate, L-Lactate, Malate, Methylmalonate (Genova), Orotate, p-Hydroxybenzoate, p-Hydroxyphenylacetate, p-Hydroxyphenyllactate, Phenylacetate, Phenylpropionate, Picolinate, Pyroglutamate (Genova), Pyruvate (Genova), Quinolinic acid (Quinolinate) (Genova), Suberate, Succinate, Sulfate, Tricarballylate, Vanilmandelate (Genova), Xanthurenate (Genova)