A healthy result should fall into the range 0 - 90 mcg/mg creatinine.

Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine.

Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body. However, unfriendly intestinal microorganisms can manufacture them in relatively high quantities.

Indican is then absorbed into the blood from the intestines and eventually appears in the urine.

Microbial overgrowth can lead to a wide variety of symptoms due to reactions to the toxic products produced by bacteria, parasites, or fungi.

If your stomach acid is not adequate, if you fail to digest protein, or if your diet does not supply sufficient fiber, the resulting overgrowth of unfavorable bacteria can release toxic products, such as indican, that your body must remove.

References:

- Greenberger N, Saegh S, and Ruppert R. Urine indican excretion in malabsorption disorders. Gastroenterol 1968;55:204-11. PMID: 4385691.

- Patney NL, Mehrotra MP, Khanna HK, Kumar A. Urinary indican excretion in cirrhosis of liver. J Assoc Physicians India. 1976 May;24(5):291-5. PMID: 1022761.

- Patney NL, Saxena SK, Mehrotra MP, Khanna HK, Kumar A. Urinary indican in diabetes mellitus. J Indian Med Assoc. 1977 Mar 1;68(5):94-7. PMID: 903638.

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