A healthy result should fall into the range 0 - 6.3 mcg/mg creatinine.
Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.
Ethylmalonate, which comes from the breakdown of butyrate, has a carnitine-dependent pathway and can accumulate with an insufficient amount of carnitine. Dietary fat, carbohydrate, and protein are all broken down to produce energy using pathways that require vitamin B2 (riboflavin).
If you do not have sufficient riboflavin, compounds such as adipate, suberate, and ethylmalonate may increase in urine.
What is Carnitine?
Carnitine helps your body use fatty acids. The body makes small amounts of carnitine.
However, if minimum requirements are not met, carnitine dependent functions fail to proceed normally. Long-chain fatty acids go through beta-oxidation in the mitochondria, which is a carnitine dependent step.
If there are inadequate amounts of carnitine, the long-chain fatty acids will get processed outside of the mitochondria; Adipate and suberate are by-products of long-chain fatty acid breakdown outside of the mitochondria.
Adipate, Suberate, and Ethylmalonate elevations indicate metabolic blocks. Carnitine is needed to move fatty acids into the mitochondria where they are converted to energy using vitamin B2. When insufficient levels of carnitine or vitamin B2 slow down this process, other parts of the cellular machinery take over and make adipate and suberate. A similar block in another pathway causes high ethylmalonate. Since most of your body’s energy is produced from the burning of fatty acids, your muscles and brain suffer when this cellular energy pathway is blocked.
Supplementation of carnitine and vitamin B2 may be needed when these compounds are too high. Insufficiency of vitamin B2 is implicated in impaired carbohydrate metabolism, migraines, and dementia. Carnitine supplementation has been documented to improve Alzheimer’s, age-related cognitive decline, and cardiac function.
$15 per monthSelect this plan
$59 per yearSelect this plan
$250 single paymentSelect this plan
Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.Get Started
"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."
"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."
"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."