A healthy result should fall into the range 0 - 6.3 mcg/mg creatinine.

Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.

Ethylmalonate, which comes from the breakdown of butyrate, has a carnitine-dependent pathway and can accumulate with an insufficient amount of carnitine. Dietary fat, carbohydrate, and protein are all broken down to produce energy using pathways that require vitamin B2 (riboflavin).

If you do not have sufficient riboflavin, compounds such as adipate, suberate, and ethylmalonate may increase in urine.

What is Carnitine?

Carnitine helps your body use fatty acids. The body makes small amounts of carnitine.

However, if minimum requirements are not met, carnitine dependent functions fail to proceed normally. Long-chain fatty acids go through beta-oxidation in the mitochondria, which is a carnitine dependent step.

If there are inadequate amounts of carnitine, the long-chain fatty acids will get processed outside of the mitochondria; Adipate and suberate are by-products of long-chain fatty acid breakdown outside of the mitochondria.

References:

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