A healthy result should fall into the range 0 - 0.9 mcg/mg creatinine.

What is α-Hydroxybutyrate?

α-Hydroxybutyrate is a by-product of glutathione production. Levels of alpha-hydroxybutyrate in the urine may reflect levels of glutathione production.

What is Glutathione?

Glutathione is an important antioxidant that can prevent damage to cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals.

Glutathione is constantly being used up in the removal of toxic molecules and prevention of oxidative damage.

α-Hydroxybutyrate is a by-product from the process in which the body forms more glutathione. When that process is running at high rates, α-hydroxybutyrate excretion is increased.

Alpha-Hydroxybutyrate result calculator

insert the value from you Alpha-Hydroxybutyrate test result.

What does it mean if your Alpha-Hydroxybutyrate result is too high?

All of the conditions associated with increased Alpha-Hydroxybutyrate excretion may be related to increased rates of hepatic glutathione synthesis from methionine. Elevated Alpha-Hydroxybutyrate thus shows increased flow through the hepatic glutathione synthesis pathway as required during times of increased oxidative stress or for detoxification functions.

  • Smoking, poor diet, and lack of exercise significantly inhibit the activity of AHBD (=Alpha-Hydroxybutyrate dehydrogenase catalyzes oxidation of AHB to acetate), suggesting that urinary elevation of Alpha-Hydroxybutyrate may be related to these factors via increased glutathione demand.
  • High Alpha-Hydroxybutyrate is also found during phases of increased lymphocyte destruction in infectious diseases such as measles.
  • Elevated Alpha-Hydroxybutyrate is found in birth asphyxia and in inherited metabolic diseases such as “cerebral” lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase deficiency, and propionic acidemia.
  • Alpha-Hydroxybutyrate is also an early marker for both insulin resistance and impaired glucose regulation that appears to arise due to increased lipid oxidation and oxidative stress.
  • Elevated levels of alpha-hydroxybutyrate in the plasma is a good marker for early-stage type II diabetes.


Upload Full Test and Learn More

To learn more, visualize and track your test results, create a personal account.

Sign Up, Upload Tests, Get Insights and Improve with HealthMatters.io.

Sign up now.

Are you concerned about your blood test results?
Then get your personal health dashboard.

$5,99/month

Personal Plan +

Unlimited Tests Upload Subscription
Cancel anytime

Sign Up

$10/test

Personal Plan Basic

Single test upload.
Pay for each test result upload.

Upload Now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.