If you can test it, we can track it — all test results, including the ones from your favorite labs.

Optimal Result: 0 - 2.3 mcg/mg creatinine.

Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. In one step of metabolism, vitamin B12 promotes the conversion of methylmalonyl CoA (a form of MMA) to succinyl Coenzyme A. If there is not enough B12 available, then the MMA concentration begins to rise, resulting in an increase of MMA in the blood and urine. The measurement of elevated amounts of methylmalonic acid in the blood or urine serves as a sensitive and early indicator of vitamin B12 deficiency.

References:

- https://labtestsonline.org/tests/methylmalonic-acid

 

What does it mean if your Methylmalonate (Genova) result is too high?

If elevated, it reflects insufficient Vitamin B12.

Common symptoms if low B12:

- Fatigue,

- poor memory,

- brain fog,

- unsteady gait,

- numbness, tingling,

- and depression

Medications that interfere with or decrease B12:

- H2 Blockers and PPIs for acid

- Metformin/Glucophage

- Birth Control Pills

- Hydrocortisone and Ciprofloxacin

Treatment considerations:

- Increase B12 foods / B12 supplementation

- Consider H.Pylori/SIBO/GUT testing

- Consider serum Intrinsic Factor or Parietal Cell Antibody testing

- Consider Biotin testing (actually causes blunted MMA but B12 symptoms)

If you can test it, we can track it — all test results, including the ones from your favorite labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 1500+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals