Succinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body. Succinic acid is a key intermediate of both the Kreb’s cycle and the electron transport chain that generates adenosine triphosphate (ATP), the currency for most of the body’s energy transactions.
Succinate is produced from bacterial degradation of unabsorbed glutamine and is a metabolite of alpha-ketogluturate, as well as methionine, valine & leucine; precursor of fumaric acid; also formed from bacterial action on glutamine.
Low succinic acid can be due to excess aluminum in your system. Low levels may indicate the need for leucine / isoleucine supplementation.
Possible causes:
Deficiencies of Fe (=Iron) or B2 (=Riboflavin) or Coenzyme Q10. Clinical signs of CoQ10 and Riboflavin deficiencies include fatigue, lassitude (=lack of energy) and myocardial and neurological degeneration. CoQ10 depletion can be tissue specific.
Additional investigations:
Treatment considerations:
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2-Methylhippurate, 3,4-Dihydroxyphenylpropionate, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, Adipate, Alpha-Hydroxybutyrate, Alpha-Keto-Beta-Methylvalerate, Alpha-Ketoglutarate, Alpha-Ketoisocaproate, Alpha-Ketoisovalerate, Benzoate, Beta-Hydroxybutyrate, Beta-Hydroxyisovalerate, cis-Aconitate, Citrate, D-Arabinitol, D-Lactate, Ethylmalonate, Formiminoglutamate, Fumarate, Glucarate, Hippurate, Histamine, Homovanillate (Genova), Hydroxymethylglutarate, Indican, Isocitrate, Ketoisovalerate, Kynurenate, L-Lactate, Malate, Methylmalonate (Genova), Orotate, p-Hydroxybenzoate, p-Hydroxyphenylacetate, p-Hydroxyphenyllactate, Phenylacetate, Phenylpropionate, Picolinate, Pyroglutamate (Genova), Pyruvate (Genova), Quinolinic acid (Quinolinate) (Genova), Suberate, Succinate, Sulfate, Tricarballylate, Vanilmandelate (Genova), Xanthurenate (Genova)
