Organix Comprehensive Profile - Urine

Alpha-Keto-Beta-Methylvalerate

Optimal Result: 0 - 1.1 mcg/mg creatinine.

Alpha-Keto-Beta-Methylvalerate is a B-Complex Vitamin Marker. Vitamins are compounds that your body needs to be healthy. Vitamins are “essential” for proper function, which means that they are not made inside your body and must be consumed in the diet. The B-complex vitamins are necessary for many enzymes in your body to function properly. Your body uses enzymes to extract energy from food, to build new tissue, to remove toxins, and to maintain the immune system. The branched-chain amino acids are broken down to form α-ketoisovalerateα-ketoisocaproate, and α-keto-β-methylvalerate.

A dehydrogensase enzyme is needed for this step. Vitamins B1, B2, B3, B5, and lipoic acid are needed for this dehydrogenase to function properly. If these nutrients are insufficient, the keto acids may build up in the urine.

References:

http://ctdbase.org/detail.go?type=chem&acc=C016211

https://www.gdx.net/uk/core-uk/interpretive-guides-uk/Organix-IG.pdf

http://www.oxfordreference.com/view/10.1093/oi/authority.20110803095405411

What does it mean if your Alpha-Keto-Beta-Methylvalerate result is too high?

Vitamins B1, B2, B3, B5, and lipoic acid are needed for this dehydrogenase to function properly. If these nutrients are insufficient, the keto acids may build up in the urine. If pyruvate and α-ketoglutarate are also both elevated, then there may be a strong need for these specific nutrients since all of them utilize a dehydrogenase enzyme

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