White Blood Cells (WBC) and Mucus in the stool can occur with bacterial and parasitic infections, with mucosal irritation, and inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis.
Elevated levels of WBCs in the stool are an indication of an inflammatory process resulting in the infiltration of leukocytes within the intestinal lumen. This could be the result of an inflammatory bowel conditions including ulcerative colitis (UC) or Crohn’s disease (check fecal calprotectin and lactoferrin). Enteroinvasive bacteria such as Campylobacter, Shigella, Salmonella, and Enteropathogenic parasites such as Giardia, Blastocystis, Cryptosporidium, and Entamoeba can be a cause of inflammation to the mucosal lining. WBCs are often accompanied by mucus in the stool (macroscopic examination). Other conditions that may be associated with WBCs in the stool include localized abscesses and anal fistulas. A positive WBC result may warrant identification and eradication of the cause of inflammation and possible anti-inflammatory therapy.
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