Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.
Immunoglobulin A (IgA) is an antibody playing a critical role in mucosal immunity and is produced in greater quantities than all other types of antibody combined.
In its secretory form, Secretory IgA is the main immunoglobulin found in mucous secretions and provides protection against potentially pathogenic microbes, due to its ability to resist degradation by enzymes and survive in harsh environments such as GI and respiratory tracts.
Secretory IgA is the first line of defense against:
- bacteria
- food residues
- yeast
- parasites
Lifestyle and nutritional factors influence levels. Choline, EFA’s, glutathione, glycine, phosphatidylcholine, Vitamin C & zinc are all needed for efficient production.
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845795/
What does it mean if your Secretory IgA result is too high?
Secretory IgA represents the first line of defense of the gastrointestinal (GI) mucosa and is central to the normal function of the GI tract as an immune barrier. Elevated fecal sIgA is an appropriate response to antigens such as pathogenic bacteria, parasites, yeast, and viruses. Eradication of the pathogenic microorganisms will bring sIgA back down into the normal range. sIgA may remain elevated up to six weeks after a GI viral infection. Elevated fecal sIgA may also be associated with autoinflammatory conditions such as reactive arthritis and spondyloarthritis. Actively breast-feeding infants may exhibit high fecal sIgA due to high maternal milk content. Consumption of bovine colostrum does not artificially increase fecal sIgA because the assay is specific for human sIgA.
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What does it mean if your Secretory IgA result is too low?
Secretory IgA represents the first line of defense of the gastrointestinal (GI) mucosa and is central to the normal function of the GI tract as an immune barrier. Immunological activity in the gastrointestinal tract can be accessed via fecal sIgA levels in a formed stool sample. However, sIgA may be artefactually low due to fluid dilution effects in a watery or loose/watery stool sample.
Chronic mental and physical stress as well as inadequate nutrition have been associated with low fecal sIgA concentrations. This includes dietary restrictions, excessive alcohol intake, body mass loss, negative moods, and anxiety. One study found decreased levels of sIgA in malnourished children, particularly protein malnourishment, which responded well to nutritional rehabilitation with a significant increase in
sIgA.
A possible explanation for this may be the synthesis and expression of sIgA requires adequate intake of the amino acid L-glutamine. An increase of dietary L-glutamine may restore GI immune function by protection of cells that synthesize sIgA. Saccharomyces boulardii is a nonpathogenic yeast that has been used for the treatment of acute infectious enteritis and antibiotic-associated diarrhea.
Restored levels of sIgA and subsequent enhanced host immune response have been found following S. boulardii administration (animal models). With low sIgA one might consider a salivary cortisol test.
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