Autoimmune Reactivity Screen

Asialoganglioside IgG+IgA

Optimal Result: 0.6 - 1.6 ELISA Index.

Gangliosides are glycosphingolipids. Asialo GM1 has important physiological properties and impacts neuronal plasticity and repair mechanisms, as well as the release of neurotrophins in the brain. Asialo GM1 acts as the site of binding for both Cholera toxin and E. coli.

Clinical Significance:

GM1 is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, however, high titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.

Autoantibodies to ganglioside GM1 are thought to be involved in the pathophysiology of some motor neuropathies due to relatively high level detection prior to therapeutic intervention, and a subsequent decrease of antibodies concurrent with clinical improvement.

High titers of IgM Antiganglioside GM1 may be etiologically important in certain types of motor neuropathy, while on the other hand, low levels of antibodies may represent B-cell dysfunctional regulation. The origin of anti-ganglioside antibodies is unknown, however, it is speculated that they can be formed against certain infectious microorganisms. Campylobacter jejuni has been identified as a frequent cause of Guillain Barré syndrome and Miller Fisher syndrome; during infection of C. jejuni anti-GM1 antibodies bind with whole cells of different C. jejuni isolates. Likewise, this occurs with Streptococcal infection, which is a trigger for PANDAS, the adult version, ANDAS and OCD.

References:

(https://www.cyrexlabs.com/Portals/0/Docs/SpecSheetPDFs/ASIALOGANGLIOSIDE.pdf)

1. Baba, et al. Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. J Neuroimmunol, 1989; 25:143-150.

2. Bansal, et al. IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. J Clin Pathol, 1994; 14:300-302.

3. Jacobs, et al. Cross-reactive antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in patients with Guillain-Barré or Miller Fisher syndrome. J Infect Disease, 1997; 175:729-733.

4. Mertens, et al. Molecular analysis of cross-reactive anti-myosin/anti-streptococcal mouse monoclonal antibodies. Molecular Immunol, 2000; 37(15):901-913.

5. Vojdani. Obsessive compulsive disorder and differentiation between non-autoimmune OCD and the autoimmune version of the disease called PANDAS. Latitudes, 6(2):1-6

6. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.

What does it mean if your Asialoganglioside IgG+IgA result is too low?

Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders.

What does it mean if your Asialoganglioside IgG+IgA result is too high?

Antibodies Appear in:

- Chronic Inflammatory Demyelinating

- Polyneuropathy

- Cerebrovascular Accidents

- Cranial Trauma

- Guillain Barre Syndrome

- Miller Fisher Syndrome

- Motor Neuron Disease

- MMNBC

- Multifocal Motor Neuropathy

- Multiple Sclerosis

- Myasthenia Gravis

- PANDAS / ANDAS / OCD

- Rheumatoid Arthritis

- Sensorimotor Neuropathy

- Systemic Lupus Erythematosus

High titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.

10 000+ happy clients
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Get Started With Our Personal Plan

Advanced Plan

  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
$79 per year
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support

Unlimited Plan

  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
$250 full version

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Plan

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free template forms
  • ✓ 3000+ biomarkers explained
  • ✓ Additional team member $25
  • ✓ Personal training and support

$45 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

×

Understand Your Lab Result Now

  • Instant interpretation
  • 3000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: