Myelin Basic Protein IgM
MYELIN BASIC PROTEIN (MBP)
Function:
Myelin is the protective sheath surrounding nerves. Myelin basic protein (MBP) is believed to be important in the process of myelination, the building of myelin sheaths. Thus, MBP is often a target in the demyelination process in various neuroimmune disorders.
References:
(https://www.cyrexlabs.com/Portals/0/Docs/SpecSheetPDFs/a5MBP.pdf)
1. Ashwood and Van de Water. Is autism an autoimmune disease? Autoimmunity Rev, 2004; 3:557-562.
2. Berger, et al. Antimyelin antibodies as a predictor of clinically definite Multiple Sclerosis after a first demyelinating event. N Engl Med, 2003; 349(2):139-145.
3. Gorgan, et al. Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice. J Immunol, 1999; 163:3764-3770.
4. Roy and Hooper. Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier. J Virol, 2007; 81(15):7993-7998.
5. Vojdani, et al. Antibodies to myelin basic protein, myelin oligodendrocytes peptides, a-B-crystallin, lymphocyte activation and cytokine production in patients with multiple sclerosis. J Internal Med, 2003; 254:363-374.
6. Vojdani. Obsessive compulsive disorder and differentiation between non-autoimmune OCD and the autoimmune version of the disease called PANDAS. Latitudes, 6(2):1-6.
7. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.
8. Ebringer, et al. Acinetobacter immune responses in multiple sclerosis. Arch Neurol, 2005; 62:33-36.
9. Mameli, et al. Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients. J Neuroimmunol, 2014; 270(1-2):51-55.
10. Kharrazian and Vojdani. Correlation between antibodies to bisphenol A, its target enzyme protein disulfide isomerase and antibodies to neuron-specific antigens. J Appl Toxicol, 2017; 37:479-484.
What does it mean if your Myelin Basic Protein IgM result is too high?
Antibodies Appear in:
- Multiple sclerosis
- Autism
- PANDAS / ANDAS / OCD
- Lupus
- Toxin exposure
Known Cross-Reactions:
- Chlamydia pneumoniae,
- Herpes-6
- streptococcal protein
- gliadin
- Acinetobacter
- Mycobacterium avium
- IgG and IgM to tissue-bound-Bisphenol A (BPA)
Clinical Significance:
MBP antibodies are detected in various neuroimmune disorders including multiple sclerosis. Consequently, antibodies to MBP are accepted markers of inflammation in various neuroimmune disorders.
In possible cases of multiple sclerosis (MS) the measurement of antibodies against MBP may predict early conversion to clinically definite MS; in a study by Berger et al patients who were seropositive for both antibodies, anti-MBP and anti-myelin oligodendrocyte glycoprotein, had clinically definite MS within a mean of 7.5 months.
To increase the sensitivity and specificity of MS diagnosis, a combination of antibodies, lymphocyte activation or cytokine production assessments along with an MRI, should be utilized.
Autism Spectrum Disorder (ASD) presents with multiple biomolecular manifestations including neurological dysfunction. Compared to control subjects, ASD patients possess significantly higher levels of anti-brain antibodies, such as MBP, serotonin receptor, and brain endothelial cells or blood-brain barrier.
Due to cross-reactivity to Streptococcal protein, MBP antibody is also found in PANDAS (pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection), its adult version ANDAS and Obsessive Compulsive Disorder (OCD).
Indeed, the similarities of peptide sequences between Streptococcal proteins and MBP result in cross-reactivity.
This autoimmune response triggers inflammation via myelin basic protein-specific T-cells, thus compromising the blood-brain barrier.
A point of interest is that the administration of myelin basic protein artificially increases blood-brain barrier permeability and is under research as a possible treatment for rabies virus, which enters the brain to replicate itself.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.