Cerebellum is the part of the brain controlling movement and balance. Inside the cerebellar cortex there are large neurons called Purkinje’s cells. The Cerebellar antibodies test measures antibodies against the cerebellum Purkinje’s Cell Antigens.
- Celiac Disease
- Gluten Ataxia
- Paraneoplastic Cerebellar Degeneration Syndrome
- Opsoclonus-Myoclonus Syndrome
gliadin, tumor cells, Milk butyrophilin
1. Balegno, et al. Antibodies to cerebellar nerve fibres in two patients with paraneoplastic cerebellar ataxia. Anticancer Research, 2005; 25:3211-3214.
2. Bernard, et al. Autism: a unique type of mercury poisoning. ARC Research, Crandford, NJ; 2000.
3. Blaes, et al. Surface-binding autoantibodies to cerebellar neurons in opsoclonus syndrome. Ann Neurol, 2005; 58:313-317.
4. Dropcho, et al. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Poc Natl Acad Sci, 1987; 84:4552-4556.
5. Hadjivassiliou, et al. The humoral response in the pathogenesis of gluten ataxia. Neurology, 2002; 58:1221-1226.
6. Vojdani et al. The immunology of gluten sensitivity beyond the intestinal tract. Eur J Inflammation, 2008; 6(2):1-6.
7. Vojdani, et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci, 2004; 7(3):151-161.
8. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Elevated Cerebellar antibodies are an indication of neuroautoimmunity. Infection, or exposure to toxic chemicals, can induce production of antibodies against Purkinje’s cells.
Due to cross-reactivity between Gliadin and Cerebellar antigens or peptides, an autoimmune reaction occurs.
Medical conditions related to Purkinje cells range from toxic exposure (mercury, alcohol) to autoimmune disorders (Celiac disease), and from genetic mutations (spinocerebellar ataxias) to neurodegenerative diseases of no known genetic basis (cerebellar multiple system atrophy, sporadic ataxias).
Although the etiology of paraneoplastic cerebellar degeneration (PCD), which generally occurs in patients with neoplasms of the lung, breast, ovary, or with Hodgkin’s disease, is unknown, scientists speculate it is autoimmune in nature.
The known cross-reactivity between cerebellar peptides and gliadin and milk butyrophilin, as seen in patients with gluten sensitivity, which includes many individuals with autism spectrum disorder (ASD), may be responsible for molecular level gluten ataxia, tremors and alterations of coordination, balance and sensations.
Exacerbating cerebellar degeneration, and bringing about the subsequent clinical conditions in ASD patients is mercury –induced disruption in cerebellar synaptic transmission between parallel fibers or climbing fibers of Purkinje cells.
According to Bernard and colleagues, due to the anti-cerebellar antibodies present in the sera of ASD patients, ongoing damage may arise as these antibodies find and react with neuronal antigens.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.Get Started
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month
21-Hydroxylase (Adrenal Cortex), Alpha + Beta Tubulin IgG+IgA, Alpha + Beta Tubulin IgM, Alpha-Myosin, Arthritic Peptide, ASCA + ANCA, Asialoganglioside IgG+IgA, Asialoganglioside IgM, Cerebellar IgG+IgA, Cerebellar IgM, Collagen Complex, Cytochrome P450 (Hepatocyte), Fibulin, Glutamic Acid Decarboxylase 65 (GAD 65), Glutamic Acid Decarboxylase Autoantibody, IA-2 Autoantibody, Insulin + Islet Cell Antigen, Intrinsic Factor, Myelin Basic Protein IgG + IgA, Myelin Basic Protein IgM, Myocardial Peptide, Osteocyte, Ovary/Testis, Parietal Cell + ATPase, Phospholipid, Platelet Glycoprotein, Synapsin IgG+IgA, Synapsin IgM, Thyroglobulin, Thyroglobulin IgG, Thyroid Peroxidase (TPO), Thyroid Peroxidase IgG, Tropomyosin