Function:
Reproductive organ tissue (Ovary, Testis) makes up the structure of female and male sex organs respectively. These organs are parts of the reproductive and endocrine systems. Ovaries secrete hormones estrogen and progesterone. Testes produce sperm and androgens, primarily testosterone.
Known Cross-Reactions:
Gliadin (Ovary high cross-reactivity, Testis slight cross-reactivity)
ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease
Autoimmune Endocrine Disorders
Autoimmune Polyendocrine Syndrome Type 1
Hypogonadism
Premature Menopause
Premature Ovarian Failure
Clinical Significance:
High levels of antibodies against reproductive organs tissue (Ovary, Testis) may indicate an autoimmune response directed at sex organ tissues. There is a high prevalence of infertility in the Celiac population.
Female: Ovarian antibodies appear in spontaneous premature ovarian failure (POF), and infertillity. POF is frequently associated with autoimmune disorders, particularly autoimmune thyroid disease. In the absence of clinically overt disease, some patients have serological evidence of autoimmunity mainly against thyroid, thus POF patients should be assessed for autoimmune thyroid disorders and conversely, thyroiditis patients should be assessed for reproductive organ antibodies.
Male: Testis antibodies appear in events of testicular trauma, polyendocrine syndrome and infertillity. Circulating antibodies to testis can occur after testicular trauma resulting in autoimmunity against male sex organ tissue. One third of unexplained infertility cases are identified as male infertility problems; an autoimmune response to testis may play a role in male infertility.
References:
Ashrafi, et al. The presence of anti thyroid and anti ovarian auto-antibodies in familial premature ovarian failure. Int J Infertility Sterility, 2008; 1(4):171-174.
Bast, et al. Celiac disease and reproductive health. Pract Gastroenterol, 2009; 35(10):10-21.
Fenichel, et al. Prevalence, specificity and significance of ovarian antibodies during spontaneous premature ovarian failure. Human Reproduction, 1997; 12(12):2623-2628.
Luborsky, et al. Ovarian antibodies, FSH and inhibin B: independent markers associated with unexplained infertility. Human Reproduction, 2000; 15:1046-1051.
Reimand, et al. Testis-expressed protein TSGA10 an auto-antigen in autoimmune polyendocrine syndrome type-I. Int Immunol, 2008; 20(1):39-44.
Sakamoto, et al. Testicular injury induces cell-mediated autoimmune response to testis. J Urol, 1995; 153:1316-1320.
Tung and Teusher. Mechanisms of autoimmune disease in the testis and ovary. Human Reproduction Update, 1995; 1(1):35-50.
Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.
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High levels of antibodies against reproductive organs tissue (Ovary, Testis) may indicate an autoimmune response directed at sex organ tissues. There is a high prevalence of infertility in the Celiac population.
Female: Ovarian antibodies appear in spontaneous premature ovarian failure (POF), and infertillity. POF is frequently associated with autoimmune disorders, particularly autoimmune thyroid disease. In the absence of clinically overt disease, some patients have serological evidence of autoimmunity mainly against thyroid, thus POF patients should be assessed for autoimmune thyroid disorders and conversely, thyroiditis patients should be assessed for reproductive organ antibodies.
Male: Testis antibodies appear in events of testicular trauma, polyendocrine syndrome and infertillity. Circulating antibodies to testis can occur after testicular trauma resulting in autoimmunity against male sex organ tissue. One third of unexplained infertility cases are identified as male infertility problems; an autoimmune response to testis may play a role in male infertility.
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Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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21-Hydroxylase (Adrenal Cortex), Alpha + Beta Tubulin IgG+IgA, Alpha + Beta Tubulin IgM, Alpha-Myosin, Arthritic Peptide, ASCA + ANCA, Asialoganglioside IgG+IgA, Asialoganglioside IgM, Cerebellar IgG+IgA, Cerebellar IgM, Collagen Complex, Cytochrome P450 (Hepatocyte), Fibulin, Glutamic Acid Decarboxylase 65 (GAD 65), Glutamic Acid Decarboxylase Autoantibody, IA-2 Autoantibody, Insulin + Islet Cell Antigen, Intrinsic Factor, Myelin Basic Protein IgG + IgA, Myelin Basic Protein IgM, Myocardial Peptide, Osteocyte, Ovary/Testis, Parietal Cell + ATPase, Phospholipid, Platelet Glycoprotein, Synapsin IgG+IgA, Synapsin IgM, Thyroglobulin, Thyroglobulin IgG, Thyroid Peroxidase (TPO), Thyroid Peroxidase IgG, Tropomyosin
