Myocardial Peptide

Optimal Result: 0 - 1.9 ELISA Index.

Array 5 Multiple Autoimmune Reactivity Screen Cyrex Laboratories

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Lab Results Explained and Tracked

Associated with :

• Autoimmune Myocarditis

• Rheumatic Heart Disease

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Function:

Myocardial Peptides make up heart structure tissues.

Antibodies Appear:

- Acute Rheumatic Fever [6]

- Autoimmune Myocarditis [1, 2]

- Heart Disease [1, 2, 3]

- Heart Trauma [3, 4, 6]

- Rheumatic Heart Disease [6]

Known Cross-Reactions:

gliadin [7]

Clinical Significance:

Myocardial Peptides are at higher levels prior to the onset of dilated cardiomyopathy, when heart dysfunction is undetectable, and will decline as the disorder evolves.[1, 2]

It is important to screen patient’s symptom-free relatives to identify those at risk, to aid in diagnosis during pre-clinical period and to potentially prevent the progression to disease state by implementing preventive therapeutic protocols. [2]

Damage to heart muscle or pericardial tissue stemming from surgery, stab wounds or acute myocardial infarctions may result in an autoimmune response to myocardial antigens. [4, 6]

Circulating autoantibodies appear 2-3 weeks after the event and subsequently drop between 3-8 weeks. [6]

However, high levels of anti-myocardial antibodies have been shown to remain in cases involving a series of injuries over an extended period in which these antibodies can persist for months or years. [6] Due to a commonality in autoimmune heart disease and Celiac disease, patients presenting with autoantibodies to heart tissue, should be assessed for Celiac disease. [5]

References:

1. Bauer, et al. Antimyocardial antibodies in the diagnosis and prognosis of coronary heart disease. Circulation, 1970; 42(Suppl3):55.

2. Caforio, et al. Cardiac autoantibodies in dilated cardiomyopathy become undetectable with disease progression. Heart, 1997; 77:62-67.

3. Cleutjens, et al. Non-invasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profiling. J Clin Invest, 2008; 118:2979-2985.

4. Engle, et al. The postpericardiotomy syndrome and antiheart antibodies. Circulation, 1974; 49:401-406.

5. Frustaci, et al. Celiac disease associated with autoimmune myocarditis. Circulation, 2002; 105:2611-26182.

6. Twomey and Bernett. Immunofluorescence method for detecting anti-myocardial antibodies, and its use in diagnosing heart disease. Clin Chem, 1975; 21(13):1903-1906Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.

7. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.

Lab Results Explained and Tracked

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What does it mean if your Myocardial Peptide result is too high?

Myocardial Peptides are at higher levels prior to the onset of dilated cardiomyopathy, when heart dysfunction is undetectable, and will decline as the disorder evolves.[1, 2]

Damage to heart muscle or pericardial tissue stemming from surgery, stab wounds or acute myocardial infarctions may result in an autoimmune response to myocardial antigens. [4, 6]

Circulating autoantibodies appear 2-3 weeks after the event and subsequently drop between 3-8 weeks. [6]

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Myocardial Peptide

All Your Lab Results. One Simple Dashboard.

What does it mean if your Myocardial Peptide result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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