Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 within distal ileum.
Clinical Significance:
Autoantibodies against Intrinsic Factor are considered highly specific to patients with Pernicious Anemia. Intrinsic Factor antibodies are rarely found in the absence of Pernicious Anemia. Less commonly, Intrinsic Factor antibodies may also be found in patients with Graves’ disease and in relatives of patients with Pernicious Anemia.
References:
1. Annabale, et al. Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis. World J Gastroenterol, 2005; 11(34):5351-5357.
2. Camel. How I treat cobalamin (vitamin B12) deficiency. Blood, 2008; 112(6):2214-2221.
3. Goldkorn, et al. Gastric parietal cell antigens of 60-90, 92 and 100-120kDa associated with autoimmune gastritis and pernicious anemia. Role of N-glycans in the structure and antigenicity of the 60-90-kDa component. J Biol Chem, 1989; 264(31):187668-18774.
4. James, et al. Cell-mediated immunity to intrinsic factor in autoimmune disorders. Br Med J, 1974; 4:494-496.
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Clinical Significance:
Autoantibodies against Intrinsic Factor are considered highly specific to patients with Pernicious Anemia. Intrinsic Factor antibodies are rarely found in the absence of Pernicious Anemia. Less commonly, Intrinsic Factor antibodies may also be found in patients with Graves’ disease and in relatives of patients with Pernicious Anemia.
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21-Hydroxylase (Adrenal Cortex), Alpha + Beta Tubulin IgG+IgA, Alpha + Beta Tubulin IgM, Alpha-Myosin, Arthritic Peptide, ASCA + ANCA, Asialoganglioside IgG+IgA, Asialoganglioside IgM, Cerebellar IgG+IgA, Cerebellar IgM, Collagen Complex, Cytochrome P450 (Hepatocyte), Fibulin, Glutamic Acid Decarboxylase 65 (GAD 65), Glutamic Acid Decarboxylase Autoantibody, IA-2 Autoantibody, Insulin + Islet Cell Antigen, Intrinsic Factor, Myelin Basic Protein IgG + IgA, Myelin Basic Protein IgM, Myocardial Peptide, Osteocyte, Ovary/Testis, Parietal Cell + ATPase, Phospholipid, Platelet Glycoprotein, Synapsin IgG+IgA, Synapsin IgM, Thyroglobulin, Thyroglobulin IgG, Thyroid Peroxidase (TPO), Thyroid Peroxidase IgG, Tropomyosin
