ASCA + ANCA

Optimal Result: 0.4 - 1.6 ELISA Index.

Array 5 Multiple Autoimmune Reactivity Screen Cyrex Laboratories Crohn's Disease

From Healthmatters.io Team

Lab Results Explained and Tracked

Function:

Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA), which is required for DNA repair, recombination, transcriptional silencing and aging. Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies against antigens in the cytoplasm of neutrophil granulocytes and monocytes.

Antibodies Appear:

Behçet’s Syndrome with GI Involvement

Crohn’s Disease

Long-term use of Anti-Thyroid Medication

Ulcerative Colitis5 Vasculitis

Clinical Significance:

Crohn’s disease (CD) and Behçet’s syndrome (BS) have clinical similarities such as oral and gastrointestinal ulcerations, erythema nodosum, arthritis and uveitis. Patients with BS who present with gastrointestinal complaints have higher levels of ASCA than BS patients with no GI conditions. Vasculitides, associated with serum positivity for ANCAs affecting small- to medium-sized vessels, are commonly recognized as ANCA-associated vasculitis. ANCAs are detected in a number of autoimmune disorders, but are particularly associated with systemic vasculitis.

ANCA positivity has been shown in a high percentage of patients on long-term anti-thyroid medication; therefore, ANCA should be tested in patients receiving long-term anti-thyroid medications, and in patients with adverse reactions. Furthermore, patients with positive ANCA should be followed, and evaluated for definitive anti-thyroid therapy, to consider alternative treatment protocols.

ASCA and ANCA are well-established markers in inflammatory bowel disease (IBD), and both may be associated with disease phenotype.

In support of diagnosis of Ulcerative Colitis, the sensitivity and specificity of ANCA were 51% and 100%, respectively. ASCA presented sensitivity of 62% and specificity of 93% for Crohn’s disease.

References:

1. Fresko, et al. Anti-Saccharomyces cerevisae antibodies (ASCA) in Behçet’s syndrome. Clin Exp Rheumatol, 2005; 23(Suppl.38):S67-S70.

2. Gómez-Puerta, et al. Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease. Chest, 2009; 136:1011-1111.

3. Gunton, et al. Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medication. Eur J Endocrinol, 2000; 142:587-590.

4. Lindberg, et al. Antibody (IgG, IgA, and IgM) to baker’s yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease. Gut, 1992; 33(7):909–913.

5. Nisihara, et al. Diagnostic role and clinical association of ASCA and ANCA in Brazilian patients with inflammatory bowel disease. Dig Dis Sci, 2010; 55(8):2309-2315.

6. Seibold, et al. pANCA represents a cross-reactivity to enteric bacterial antigens. J Clin Immunol, 1998; 18(2):153-160.

Lab Results Explained and Tracked

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What does it mean if your ASCA + ANCA result is too high?

Clinical Significance:

ASCA and ANCA are well-established markers in inflammatory bowel disease (IBD), and both may be associated with disease phenotype.

In support of diagnosis of Ulcerative Colitis, the sensitivity and specificity of ANCA were 51% and 100%, respectively. ASCA presented sensitivity of 62% and specificity of 93% for Crohn’s disease.

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ASCA + ANCA

All Your Lab Results. One Simple Dashboard.

What does it mean if your ASCA + ANCA result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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