Function:
Collagen is a group of proteins found in the flesh and connective tissues. The most abundant protein of the human body, Collagen is the main component of connective tissue. Collagen is found in tissues such as tendon, ligament and skin, and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell which creates collagen. In muscle tissue, collagen serves as a major component of the endomysium.
Antibodies Appear:
Arthritis [4]
Goodpasture’s Syndrome (*rat study) [1]
Type 1 Bullous SLE [3]
Known Cross-Reactions:
Clostridium botulinum, RNA polymerase 20–32, Streptococcus pyogenes; [1] Porphyromonas gingivalis; [5,6] Klebsiella; [7] Chicken collagen; [8] Cow, Pig, Goat and Dog collagen; [9] Cow gelatin [10]
Clinical Significance:
High levels of antibodies to Collagen Complex are noted in autoimmune arthritic disorders. [3, 4]
Circulating antibodies to collagen appear years before the clinical onset of arthritic conditions and is therefore considered an early biomarker or predictor of autoimmune arthritis. [2]
Blistering seen in bullous systemic lupus erythematosus may not always be widespread as shown by Fujii et al, [3] they can develop on limited parts of the body. Circulating collagen antibodies demonstrate the involvement of an autoimmune mechanism. [3]
In a rat study, Arends et al. were able to show that infections with microbial peptides may induce antiglomerular basement membrane disease or Goodpasture’s syndrome through T cell epitope mimicry. [1]
References:
1. Arends, et al. T cell epitope mimicry in antiglomerular basement membrane disease. J Immunol, 2006; 176:1252-1258.
2. Dzhambazov, et al. Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules. J Immunol, 2006; 176:1525-1533.
3. Fujii, et al. Detection of anti-type VII collagen antibody in Sjögren’s syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus. Br J Dermatol, 1998; 139:302-306.
4. Khare, et al. Oral administration of immunodominant human collagen peptide modulates collagen-induced arthritis. J Immunol, 1995; 155(7):3653-3659.
5. Vojdani. A potential link between environmental triggers and autoimmunity. Autoimmune Dis, 2014; 2014:437231.
6. Lundberg, et al. Periodontitis in RA – the citrullinated enolase connection. Nat Rev Rheumatol, 2010; 6(12):727-30.
7. Ebringer, et al. Ankylosing spondylitis, HLA-B27 and Klebsiella - an overview: proposal for early diagnosis and treatment. Curr Rheumatol Rev, 2006; 2(1):289-297.
8. Petkovic and Metlas. Cross-reactivity of the V3-specific antibodies with the human C1q. Z Naturforsch C, 2001; 56(11- 12):1135-1143.
9. Werkmeister, et al. Characterisation of a monoclonal antibody against native human type I collagen. Eur J Biochem, 1990; 187:439-443.
10. Sakaguchi, et al. Reactivity of IgE and IgG antibodies to human collagen type 1 in children with bovine gelatin allergy. J Allergy Clin Immunol, 2004; 113(2):S181.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
High levels of antibodies to Collagen Complex are noted in autoimmune arthritic disorders. [3, 4]
Circulating antibodies to collagen appear years before the clinical onset of arthritic conditions and is therefore considered an early biomarker or predictor of autoimmune arthritis. [2]
Blistering seen in bullous systemic lupus erythematosus may not always be widespread as shown by Fujii et al, [3] they can develop on limited parts of the body. Circulating collagen antibodies demonstrate the involvement of an autoimmune mechanism. [3]
In a rat study, Arends et al. were able to show that infections with microbial peptides may induce antiglomerular basement membrane disease or Goodpasture’s syndrome through T cell epitope mimicry. [1]
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedOur specialized data entry service is designed to seamlessly integrate your laboratory results into your private dashboard. Just send in your lab test results—whether it's an image or a file—and our skilled data entry team will handle the rest. We accommodate various file formats like PDFs, JPGs, and Excel.
The first report is complimentary. After that, the data entry service is priced at $15 per report, unless it's part of your subscribed plan. It's an ideal solution whether you have numerous reports to upload or if your schedule doesn't permit self-data entry.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
$250/once
own it for life
$45/month
for health professionals
Personal Account
$15/month
for personal lab results
$250/once
own it for life
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Unlock additional Pro plans when you sign up.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
21-Hydroxylase (Adrenal Cortex), Alpha + Beta Tubulin IgG+IgA, Alpha + Beta Tubulin IgM, Alpha-Myosin, Arthritic Peptide, ASCA + ANCA, Asialoganglioside IgG+IgA, Asialoganglioside IgM, Cerebellar IgG+IgA, Cerebellar IgM, Collagen Complex, Cytochrome P450 (Hepatocyte), Fibulin, Glutamic Acid Decarboxylase 65 (GAD 65), Glutamic Acid Decarboxylase Autoantibody, IA-2 Autoantibody, Insulin + Islet Cell Antigen, Intrinsic Factor, Myelin Basic Protein IgG + IgA, Myelin Basic Protein IgM, Myocardial Peptide, Osteocyte, Ovary/Testis, Parietal Cell + ATPase, Phospholipid, Platelet Glycoprotein, Synapsin IgG+IgA, Synapsin IgM, Thyroglobulin, Thyroglobulin IgG, Thyroid Peroxidase (TPO), Thyroid Peroxidase IgG, Tropomyosin