Function:
Collagen is a group of proteins found in the flesh and connective tissues. The most abundant protein of the human body, Collagen is the main component of connective tissue. Collagen is found in tissues such as tendon, ligament and skin, and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell which creates collagen. In muscle tissue, collagen serves as a major component of the endomysium.
Antibodies Appear:
Arthritis [4]
Goodpasture’s Syndrome (*rat study) [1]
Type 1 Bullous SLE [3]
Known Cross-Reactions:
Clostridium botulinum, RNA polymerase 20–32, Streptococcus pyogenes; [1] Porphyromonas gingivalis; [5,6] Klebsiella; [7] Chicken collagen; [8] Cow, Pig, Goat and Dog collagen; [9] Cow gelatin [10]
Clinical Significance:
High levels of antibodies to Collagen Complex are noted in autoimmune arthritic disorders. [3, 4]
Circulating antibodies to collagen appear years before the clinical onset of arthritic conditions and is therefore considered an early biomarker or predictor of autoimmune arthritis. [2]
Blistering seen in bullous systemic lupus erythematosus may not always be widespread as shown by Fujii et al, [3] they can develop on limited parts of the body. Circulating collagen antibodies demonstrate the involvement of an autoimmune mechanism. [3]
In a rat study, Arends et al. were able to show that infections with microbial peptides may induce antiglomerular basement membrane disease or Goodpasture’s syndrome through T cell epitope mimicry. [1]
References:
1. Arends, et al. T cell epitope mimicry in antiglomerular basement membrane disease. J Immunol, 2006; 176:1252-1258.
2. Dzhambazov, et al. Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules. J Immunol, 2006; 176:1525-1533.
3. Fujii, et al. Detection of anti-type VII collagen antibody in Sjögren’s syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus. Br J Dermatol, 1998; 139:302-306.
4. Khare, et al. Oral administration of immunodominant human collagen peptide modulates collagen-induced arthritis. J Immunol, 1995; 155(7):3653-3659.
5. Vojdani. A potential link between environmental triggers and autoimmunity. Autoimmune Dis, 2014; 2014:437231.
6. Lundberg, et al. Periodontitis in RA – the citrullinated enolase connection. Nat Rev Rheumatol, 2010; 6(12):727-30.
7. Ebringer, et al. Ankylosing spondylitis, HLA-B27 and Klebsiella - an overview: proposal for early diagnosis and treatment. Curr Rheumatol Rev, 2006; 2(1):289-297.
8. Petkovic and Metlas. Cross-reactivity of the V3-specific antibodies with the human C1q. Z Naturforsch C, 2001; 56(11- 12):1135-1143.
9. Werkmeister, et al. Characterisation of a monoclonal antibody against native human type I collagen. Eur J Biochem, 1990; 187:439-443.
10. Sakaguchi, et al. Reactivity of IgE and IgG antibodies to human collagen type 1 in children with bovine gelatin allergy. J Allergy Clin Immunol, 2004; 113(2):S181.
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High levels of antibodies to Collagen Complex are noted in autoimmune arthritic disorders. [3, 4]
Circulating antibodies to collagen appear years before the clinical onset of arthritic conditions and is therefore considered an early biomarker or predictor of autoimmune arthritis. [2]
Blistering seen in bullous systemic lupus erythematosus may not always be widespread as shown by Fujii et al, [3] they can develop on limited parts of the body. Circulating collagen antibodies demonstrate the involvement of an autoimmune mechanism. [3]
In a rat study, Arends et al. were able to show that infections with microbial peptides may induce antiglomerular basement membrane disease or Goodpasture’s syndrome through T cell epitope mimicry. [1]
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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21-Hydroxylase (Adrenal Cortex), Alpha + Beta Tubulin IgG+IgA, Alpha + Beta Tubulin IgM, Alpha-Myosin, Arthritic Peptide, ASCA + ANCA, Asialoganglioside IgG+IgA, Asialoganglioside IgM, Cerebellar IgG+IgA, Cerebellar IgM, Collagen Complex, Cytochrome P450 (Hepatocyte), Fibulin, Glutamic Acid Decarboxylase 65 (GAD 65), Glutamic Acid Decarboxylase Autoantibody, IA-2 Autoantibody, Insulin + Islet Cell Antigen, Intrinsic Factor, Myelin Basic Protein IgG + IgA, Myelin Basic Protein IgM, Myocardial Peptide, Osteocyte, Ovary/Testis, Parietal Cell + ATPase, Phospholipid, Platelet Glycoprotein, Synapsin IgG+IgA, Synapsin IgM, Thyroglobulin, Thyroglobulin IgG, Thyroid Peroxidase (TPO), Thyroid Peroxidase IgG, Tropomyosin
