Class-switched CD27+IgD-IgM- B cells are a specialized subset of memory B cells that have undergone immunoglobulin class switch recombination (CSR). This process enables B cells to transition from producing IgM and IgD to other immunoglobulin isotypes, such as IgG, IgA, or IgE, while maintaining their antigen specificity. These cells are defined by the expression of CD27, a hallmark of memory B cells, and the absence of surface IgD and IgM.
Class-switched memory B cells are essential for adaptive immunity, enabling the rapid production of high-affinity antibodies upon re-exposure to previously encountered antigens. CSR occurs through a deletional recombination event between switch (S) regions upstream of constant region genes, allowing the variable region to pair with different constant regions, thus broadening the immune response.
The formation of these cells primarily takes place in germinal centers, where they undergo processes such as affinity maturation and somatic hypermutation. However, some class-switched memory B cells can develop independently of germinal center reactions. Upon antigen re-exposure, these cells may re-enter germinal centers to undergo further diversification and fine-tuning of their B cell receptors.
Alterations in the frequency of class-switched memory B cells can signal immune dysfunction. Reduced levels are often observed in conditions like common variable immunodeficiency (CVID), while their association with autoimmune diseases or chronic infections is more nuanced and condition-specific.
Monitoring the proportion of these cells provides valuable insights into the immune system's ability to generate and sustain antigen-specific responses. However, interpreting these levels requires a comprehensive assessment of overall immune function and the individual’s clinical context.
Elevated levels of Class-switched CD27+IgD-IgM- % refer to a higher percentage of memory B cells that have undergone class-switch recombination, which means they've switched their antibody class from IgM (the first antibody produced during an immune response) to other antibody classes, such as IgG, IgA, or IgE. These cells express CD27, a marker for memory B cells, and IgD-IgM- indicates that these cells no longer express IgD or IgM, which are present on naive B cells.
Chronic Infection or Repeated Exposure: A higher percentage of class-switched memory B cells can indicate that the immune system has been repeatedly exposed to antigens, often from chronic infections or long-term exposure to pathogens.
Autoimmune Diseases: Conditions like lupus or rheumatoid arthritis, where the immune system is overactive and targets the body's own tissues, can lead to an increase in class-switched memory B cells. These cells might play a role in sustaining the autoimmune process.
Vaccination or Immunization: Elevated levels could also be a sign of a robust immune response after vaccination, especially when the immune system has successfully class-switched to generate more effective antibodies for long-term immunity.
B-cell Dysregulation or Hyperactivation: In some cases, this could be related to B-cell dysregulation, where the immune system is producing an excess of memory B cells that have switched antibody classes. This can sometimes be seen in conditions like B-cell lymphoma or other hematologic conditions.
Elevated class-switched CD27+IgD-IgM- % can be a marker of a heightened immune response, either from infection, autoimmune activity, or vaccination. It’s important to interpret this result in context with other markers and clinical findings to understand its full significance.
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Low levels of Class-switched CD27+IgD-IgM- % (Class-switched CD27+ IgD-IgM- Percentage) can provide insights into the functionality of the adaptive immune system, particularly in terms of memory B cell differentiation and the body’s ability to respond to infections or vaccines effectively. This biomarker refers to B cells that have undergone class switching (from IgM and IgD to other immunoglobulin classes such as IgG, IgA, or IgE) and are identified by the presence of CD27 on their surface, indicating that these cells have been exposed to antigens and have become part of the immune system's memory. Low levels of this marker can be significant in several ways.
To understand the implications of low levels, let's break down the significance of Class-switched CD27+IgD-IgM- B cells:
Class Switching: This is a process by which B cells change the class of antibodies they produce in response to an infection or other immune challenges. Initially, B cells produce IgM antibodies, but class switching allows them to produce other types such as IgG, IgA, or IgE, which are more specialized for specific types of immune responses.
CD27+: This marker identifies memory B cells, which have previously encountered and responded to antigens (pathogens or vaccines). The presence of CD27 indicates that the B cell is part of the immune system's long-term memory and can quickly respond to future exposures to the same pathogen.
IgD-IgM-: These markers show that the B cells have already undergone class switching, meaning they are no longer expressing IgD or IgM antibodies on their surface. Instead, these B cells have switched to producing other types of antibodies like IgG, IgA, or IgE.
Immunodeficiency or Inability to Mount Adequate Immune Responses Low levels of Class-switched CD27+IgD-IgM- % can indicate a problem with the immune system’s ability to mount a robust, long-lasting immune response. This might be due to:
Common Variable Immunodeficiency (CVID): This condition results in a failure to produce sufficient antibodies in response to infections. In CVID, there can be a reduction in class-switched memory B cells, meaning the body struggles to generate protective immunity after exposure to pathogens or vaccination.
Selective Immunoglobulin Deficiencies: In some cases, low levels of class-switched memory B cells may indicate that the body cannot produce sufficient amounts of IgG, IgA, or IgE in response to infections, leading to recurrent infections and an impaired ability to develop immunity.
Failure to Develop Immune Memory After Infection or Vaccination Class-switched CD27+IgD-IgM- B cells are a key part of the body’s immune memory, which allows for a faster and more efficient response to previously encountered pathogens. Low levels may indicate:
Inability to generate immune memory: If the immune system cannot class-switch B cells or produce memory B cells effectively, the body may fail to develop long-term immunity after infections or vaccinations. This could result in poor responses to vaccines, leaving individuals more vulnerable to infections.
Poor response to vaccinations: People with low levels of class-switched memory B cells may fail to produce protective antibodies after immunization, leading to reduced vaccine efficacy.
Autoimmune Conditions In some autoimmune diseases, the immune system is dysregulated, leading to problems with B cell differentiation. Low levels of class-switched memory B cells might be associated with:
Autoimmune Diseases (e.g., Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis): In autoimmune conditions, B cell function is often impaired or altered. Some autoimmune diseases can affect the regulation of class-switching, leading to an imbalance in the number of memory B cells and a diminished capacity to produce effective antibodies.
Chronic Infections or Persistent Inflammation Chronic infections or persistent inflammation can lead to the depletion of class-switched memory B cells over time. In this case, low levels may suggest:
Chronic immune activation: Conditions like HIV, hepatitis, or other chronic infections can exhaust the immune system, leading to a reduction in memory B cells that have undergone class switching. This could result in a less effective immune response over time.
Immune exhaustion: Prolonged activation of the immune system may lead to the exhaustion of immune cells, including B cells. When this happens, the body’s ability to generate new class-switched memory B cells can be impaired, leading to low levels of this biomarker.
Aging (Immunosenescence) As people age, their immune system undergoes changes, including a reduction in the number and function of various immune cells, including memory B cells. This natural decline in immune function is called immunosenescence, and low levels of Class-switched CD27+IgD-IgM- % may be a sign of:
Reduced immune memory: Aging leads to fewer class-switched memory B cells, which can result in slower or less effective immune responses, as well as a diminished capacity to respond to new infections or recall previous infections.
Nutritional deficiencies or chronic illness can impair immune cell development, leading to low levels of memory B cells. Specific deficiencies (e.g., lack of vitamins or minerals) can hinder B cell maturation and function, including class switching. In such cases, low levels of class-switched memory B cells might indicate:
Impaired immune function due to malnutrition or chronic illness, potentially leading to recurrent infections or slow recovery from illness.
Low levels of Class-switched CD27+IgD-IgM- % typically reflect an impaired ability to generate an effective, long-lasting immune response. This could be due to immunodeficiency disorders, chronic infections, autoimmune diseases, aging, or other factors affecting immune function. Further investigation is needed to determine the underlying cause, and such findings may guide clinicians in tailoring treatment or monitoring strategies to improve immune health.
Laboratories
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About membership
Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
See Your Health Timeline
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
Understand What Your Results Mean
Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Anthony
Unlimited Plan Member since 2021
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Karin
Advanced Plan Member since 2020
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Paul
Healthmatters Pro Member since 2024
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Optimal Result:
5.1 - 22 % of CD19.