The CD4 percentage (CD4%) is the percentage of white blood cells (lymphocytes) that are CD4 cells.
The immune system contains lots of different cells. The two main types of lymphocytes are T cells and B cells. CD4 cells are a type of T cell. So the CD4% looks at the CD4 count in relation to other immune cells.
CD4% is sometimes a more stable indication of whether there has been a change in the immune system. If the percentage hasn’t changed the change in the absolute count is not important.
The normal range for HIV-negative adults is 30% to 60%; people with HIV often have a lower percentage. A percentage below 14% indicates an AIDS diagnosis. CD4 percentage, rather than CD4 count, is used to monitor disease progression in children.
CD4% is sometimes a more stable indication of whether there has been a change in the immune system. If the percentage hasn’t changed the change in the absolute count is not important.
- A CD4% of 12-15% is about the same as a count of under 200 cells/mm3.
- A CD4% of 29% is about the same as a count of over 500 cells/mm3, but there is a wider range for higher values.
- The average normal CD4 percentage for someone who is HIV negative is about 40%. The normal range is anywhere from about 25% to 65%.
The CD4% count is also used to monitor children under 12 years old. This is because babies are born with very high CD4 levels. A baby can have a CD4 count that is 3000 cells/mm3.
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In addition to using a test to count the number of CD4 cells, doctors sometimes measure the proportion of all white blood cells that are CD4 cells. This is called a CD4 cell percentage. Although it’s not recommended that CD4 percentages are used as a general indicator of the health of an adult’s immune system, there can be situations where it is a useful measurement. For example, if your CD4 percentage is very different to your CD4 cell count, it might be a sign of another health problem.
One circumstance when your doctor might measure your CD4 cell percentage could be if there is a big variation in your CD4 cell count between one test and the next. CD4 percentages are less likely to fluctuate than CD4 counts.
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A decreased percentage of CD4+ T cells, also known as helper T cells, in the blood is a concerning finding as it can indicate a weakened immune system. CD4+ T cells play a crucial role in regulating the immune response and coordinating the body's defense against infections. A decrease in the percentage of CD4+ T cells can be associated with conditions that suppress the immune system, such as HIV (Human Immunodeficiency Virus) infection, which specifically targets and depletes CD4+ T cells. As the CD4+ T cell count declines, the immune system becomes less effective at fighting off infections, making the individual more susceptible to various illnesses and opportunistic infections. Monitoring CD4+ T cell levels is essential in managing conditions like HIV and guiding treatment decisions to support immune health. If you have concerns about a decreased percentage of CD4+ T cells, it's crucial to consult with a healthcare provider for a thorough evaluation and appropriate management.
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% CD19 (B Cells), % CD3 (Mature T Cells), % CD3+CD25+ Lymphs, % CD4, % CD8, Abs.CD3+CD25+ Lymphs, Absolute CD19+ Cells, Absolute CD3+ Cells, Absolute CD4+ Cells, Absolute CD45 Count, Absolute CD8+ Cells, Absolute Lymphocytes, Absolute T-Suppressor Cells, Activated CD21 low CD38- %, Activated CD21 low CD38- Abs, CD20+ %, CD20, Abs Count, CD3-/CD16+CD56+ (%), CD3-/CD16+CD56+ (Absolute), CD4/CD8 Ratio, CD57+ NK-cells (%), CD57+ NK-cells (absolute), Class-switched CD27+IgD-IgM- %, Class-switched CD27+IgD-IgM- Abs, Lymph CD16&56 (NK) %, Lymphocyte Absolute CD16&56 (NK) Count, NATURAL KILLER CELLS CD3-CD16+CD56+ (ABS), NK Cells (CD16/CD56), Non switched CD27+IgD+IgM+ %, Non switched CD27+IgD+IgM+ Abs, Plasmablasts CD38+IgM- %, Plasmablasts CD38+IgM- Abs, T-Helper/Suppressor Ratio, Total Memory CD27+ %, Total Memory CD27+ Abs, Total NK Cells (CD16/CD56), Transitional CD38+IgM+ %, Transitional CD38+IgM+ Abs
