Malate

Optimal Result: 0 - 3 mmol/mol creatinine.

Malate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism. This cycle critically supports organ maintenance and neurological function.

What does it mean if your Malate result is too low?

- A deficiency in one or more Krebs’ cycle intermediates and an inhibition of normal energy production may cause a wide range of metabolic disturbances and symptoms.

- Low levels can indicate a general amino acid insufficiency.

What does it mean if your Malate result is too high?

- Higher levels of Malate in urine indicates inefficiencies in energy production.

- Coenzyme Q10 deficiency causes elevation of this intermediate.

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