Phenylacetate is produced from bacterial degradation of unabsorbed phenylalanine.
In health, beneficial intestinal bacteria produce some B-vitamins and provide stimulus for proper immune function. However, if your stomach acid is not adequate, if you fail to digest protein, or if your diet does not supply sufficient fiber, the resulting overgrowth of unfavorable bacteria can release toxic products that your body must remove. These toxic products include: Phenylacetate.
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Elevated Phenylacetate in the urine suggests incomplete digestion and absorption of phenylalanine in the intestine, allowing colonic bacteria to convert phenylalanine to Phenylacetate. Elevations may also reflect an overgrowth of bacteria, which convert phenylalanine to Phenylacetate.
Dietary polyphenols may also contribute to Phenylacetate elevation.
Clinical Associations: There is a clinical correlation between decreased urinary PAA and depressive symptoms.
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Possible causes:
• Malabsorption of phenylalanine
• Hypochlorhydria and/or Clostridia overgrowth
Additional investigations if high:
• Investigate possible causes of malabsorption
• IP
• IgG Food Sensitivity
• CDSA
Treatment considerations if high:
• Mucosal support
• Elimination diet
• Betaine HCl
• Digestive enzymes
Your potential to benefit from consuming extra sources of favorable organisms (called probiotics) may go up as the number of toxic compounds and their concentrations increase.
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3,4-Dihydroxyphenylpropionate, 3-Methyl-4-OH-phenylglycol, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, a-Hydroxybutyrate, a-Hydroxyisobutyrate, a-Keto-b-Methylvalerate, a-Ketoadipate, a-Ketoglutarate, a-Ketoisocaproate, a-Ketoisovalerate, a-Ketophenylacetate, Adipate, b-Hydroxybutyrate, b-Hydroxyisovalerate, b-Hydroxypropionate, Benzoate, Cis-Aconitate, Citramalate, Citrate, D-Arabinitol, Formiminoglutamate, Glutarate, Glycerate, Glycolate, Hippurate, Homovanillate, Hydroxymethylglutarate, Indoleacetate, Isocitrate, Isovalerylglycine, Kynurenate, Kynurenate/Quinolinate, Lactate, m-Hydroxyphenylacetate, Malate, Methylmalonate, Orotate, Oxalate, p-Hydroxyphenylacetate, Phenylacetate, Pyroglutamate, Pyruvate, Quinolinate, Suberate, Succinate, Tartarate, Vanilmandelate, Xanthurenate
