Formiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.
Pregnant women especially need to have adequate folic acid to prevent birth defects. Folic acid insufficiency can play a role in childhood development problems, depression, immune function, and is a risk factor for cardiovascular disease.
Insufficiency of folic acid leads to high urinary Formiminoglutamate.
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High levels can indicate:
- insufficient folic acid
- increased alcohol consumption
- excessive consumption of processed foods
- oral contraception
Smoking and pregnancy will all have a detrimental impact on folic acid absorption.
Symptoms:
Common symptoms may include:
- anemia
- fatigue
- elevated homocysteine
- ischemic heart disease
- stroke
- deep vein thrombosis.
Pregnant women especially need to have adequate folic acid to prevent birth defects.
Folic acid insufficiency can play a role in:
- childhood development problems
- depression
- immune function
Folic acid insufficiency is a risk factor for cardiovascular disease.
Possible treatment options if high:
- consider supplementing with folic acid.
- stop consumption of alcohol.
- if homocysteine is elevated, consider using 5-methyltetrahydrofolate.
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3,4-Dihydroxyphenylpropionate, 3-Methyl-4-OH-phenylglycol, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, a-Hydroxybutyrate, a-Hydroxyisobutyrate, a-Keto-b-Methylvalerate, a-Ketoadipate, a-Ketoglutarate, a-Ketoisocaproate, a-Ketoisovalerate, a-Ketophenylacetate, Adipate, b-Hydroxybutyrate, b-Hydroxyisovalerate, b-Hydroxypropionate, Benzoate, Cis-Aconitate, Citramalate, Citrate, D-Arabinitol, Formiminoglutamate, Glutarate, Glycerate, Glycolate, Hippurate, Homovanillate, Hydroxymethylglutarate, Indoleacetate, Isocitrate, Isovalerylglycine, Kynurenate, Kynurenate/Quinolinate, Lactate, m-Hydroxyphenylacetate, Malate, Methylmalonate, Orotate, Oxalate, p-Hydroxyphenylacetate, Phenylacetate, Pyroglutamate, Pyruvate, Quinolinate, Suberate, Succinate, Tartarate, Vanilmandelate, Xanthurenate
