8-hydroxy-2-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.
8-hydroxy-2-deoxyguanosine is a non-invasive marker of cell damage. Some cell damage is a normal part of metabolism, but it is kept to a minimum by the cell’s protective mechanisms. Under certain circumstances, the balance between the damaging chemicals and protective mechanisms can be upset, resulting in a condition termed “oxidative stress.” Although numerous cell damage products can be formed, the one most often studied is 8-OHdG. When oxidative damage occurs to the cells, repair mechanisms produce 8-OHdG, which is excreted unchanged in the urine. High levels reflect high oxidative stress to the cells.a
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Consider supplementing with Vitamin C, E, lipoic acid and NAC. Also consider using green tea, grapes and berries. Although an increase consumption of alcohol will have a detrimental impact on this marker, an occasional glass of red wine may be of value due to its high level of flavonoids.
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3,4-Dihydroxyphenylpropionate, 3-Methyl-4-OH-phenylglycol, 5-Hydroxyindoleacetate, 8-Hydroxy-2-deoxyguanosine, a-Hydroxybutyrate, a-Hydroxyisobutyrate, a-Keto-b-Methylvalerate, a-Ketoadipate, a-Ketoglutarate, a-Ketoisocaproate, a-Ketoisovalerate, a-Ketophenylacetate, Adipate, b-Hydroxybutyrate, b-Hydroxyisovalerate, b-Hydroxypropionate, Benzoate, Cis-Aconitate, Citramalate, Citrate, Creatinine, D-Arabinitol, Formiminoglutamate, Glutarate, Glycerate, Glycolate, Hippurate, Homovanillate, Hydroxymethylglutarate, Indoleacetate, Isocitrate, Isovalerylglycine, Kynurenate, Kynurenate/Quinolinate, Lactate, m-Hydroxyphenylacetate, Malate, Methylmalonate, Orotate, Oxalate, p-Hydroxyphenylacetate, Phenylacetate, Pyroglutamate, Pyruvate, Quinolinate, Suberate, Succinate, Tartarate, Vanilmandelate, Xanthurenate