2,4-Dichlorophenoxyacetic Acid (2-,4-D)

Optimal result: 0 – 0.2 µg/g creatinine

2,4-D was an ingredient in Agent Orange, and is most commonly used in agriculture of genetically modified foods, and as a weed killer for lawns.

Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden.

Small amounts of 2,4-dichlorophenoxyacetic acid may be found in many urine samples because of widespread environmental contamination. The risk factors associated with low-level exposure are not well established. High values may be treated by removing the person from likely sources of exposure. Elimination of 2,4-D can also be accelerated by sauna treatment, the Hubbard detoxification protocol employing niacin supplementation, vitamin B-12 therapy, by glutathione (reduced) supplementation (oral, intravenous, transdermal, or precursors such as N-acetyl cysteine [NAC]).

If children have high values, parents should avoid lawn chemicals and prevent their children from playing on lawns that use such chemicals.

2,4-Dichlorophenoxyacetic Acid (2,4-D) is a very common herbicide that was a part of Agent Orange, which was used by the U.S. in the Vietnam War. It is most commonly used in agriculture on genetically modified foods, and as a weed killer for lawns. Exposure to 2, 4-D via skin or oral ingestion is associated with neuritis, weakness, nausea, abdominal pain, headache, dizziness, peripheral neuropathy, stupor, seizures, brain damage, and impaired reflexes. 2, 4-D is a known endocrine disruptor, and can block hormone distribution and cause glandular breakdown.

2,4-dichlorophenoxyacetic acid (2,4-D) can result from exposure to this very common herbicide that was a part of a chemical mixture called Agent Orange, used by the U.S. during the Vietnam War to increase the visibility for war planes by destroying plant undergrowth and crops.

Herbicides are chemical agents intended to kill unwanted vegetation such as broadleaf weeds and woody plants. They are used in agriculture and on residential properties. People can be exposed to herbicides by breathing them or by skin contact from their residential use or living near application sites, and by eating contaminated food and drinking contaminated water.

- Mean urinary levels of 2,4-D among workers involved in mixing, loading, and applying this herbicide ranged from 5 to 837 μg /L.

- Median urine 2,4-D concentrations at baseline and a day after application of this herbicide were 2.1 and 73.1 μg/L for farming applicators, and 1.5 and 2.9 μg/L for their children.

- 2,4-D has a half-life of approximately 12-36 h.

Health issues:

- Neuritis, weakness, nausea, abdominal pain, headache, dizziness, peripheral neuropathy, stupor, seizures, brain damage, and impaired reflexes have been associated with dermal or oral exposure.

- 2,4-D is a known endocrine disruptor, and can block hormone distribution and cause glandular breakdown.

- It is linked to immune system damage, birth defects and reproductive issues possibly due to its frequent contamination with dioxins.

2,4-Dichlorophenoxyacetic Acid (2-,4-D)
Healthmatters dashboard showing biomarker trend graph

Every lab result you’ve ever had, charted and explained.

Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.

Start with my report →
Beyond 2,4-Dichlorophenoxyacetic Acid (2-,4-D) — 10,000+ markers explained
One 2,4-Dichlorophenoxyacetic Acid (2-,4-D) result tells you where you are. Your history tells you where you’re heading. Upload your past lab reports and see this marker — and every marker on them —every marker charted against your own lab’s ranges.
Start with this report →
Healthmatters timeline preview showing biomarker trends over time
Clinical Sources & References

All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.

Article Review Log
Written by Healthmatters Editorial Team
Healthmatters Lifetime Plan

Pay $250. Track your health forever

One payment. No renewals. Yours for life.

10,000+ biomarkers explained · trends over time

See other plans →
Secure checkout via Stripe · GDPR & HIPAA
We accept results from any lab
LabCorp Quest Diagnostics Genova Diagnostics DUTCH Test Doctor's Data Vibrant America ZRT Laboratory Cyrex Labs + any other lab

What members are saying

★★★★★ 10,000+ happy members
★★★★★

"Watching my numbers move over the years — instead of forgetting last time's results — completely changed how I manage my health."

Daniel
Member since 2022
★★★★★

"Living across several countries made keeping my lab results organized a real challenge. Healthmatters brought my results from the USA, Spain, and Germany together — 20 years of history, with long-term trends instead of scattered reports."

Ben
Member since 2021 · tracks across countries
★★★★★

"Standard lab ranges are too wide for how I practice — 'normal' isn't optimal. I set my own bands, so a client sees yellow before a marker goes officially out of range. That's the conversation I want to be having."

Dr. Alexandra
Functional medicine · 6 yrs on Pro