N-Acetyl(3,4-dihydroxybutyl) cysteine (NADB) is a result of the exposure to 1,3 butadiene and NABD is the major metabolite. This metabolite is evidence of exposure to synthetic rubber such as tires. The primary route of exposure is inhalation. Some exposure may occur through ingestion of contaminated food or water or through dermal contact. Newer playgrounds and athletic fields are now made with ground up tires, which may lead to increased exposure for children. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease.
N-Acetyl(3,4-dihydroxybutyl) cysteine (NADB) is a chemical made from the processing of petroleum. It is often a colorless gas with a mild gasoline-like odor. Most of this chemical is used in the production of synthetic rubber. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin. The increased use of old tires in the production of crumb rubber playgrounds and athletic fields is quite concerning since soccer players on such fields have increased cancer rates.
Elimination of 1,3 butadiene can be accelerated by the supplementation of glutathione (reduced) either oral, intravenous, transdermal, or its precursor N-acetyl cysteine(NAC).
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