N-acetyl(3,4-dihydroxybutyl)cysteine (NADB)

Optimal result: 0 – 4 µg/g creatinine

By Healthmatters Editorial Team

Peer-reviewed sources

N-Acetyl(3,4-dihydroxybutyl) cysteine (NADB) is a chemical made from the processing of petroleum. It is often a colorless gas with a mild gasoline-like odor. Most of this chemical is used in the production of synthetic rubber. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin. The increased use of old tires in the production of crumb rubber playgrounds and athletic fields is quite concerning since soccer players on such fields have increased cancer rates.

Elimination of 1,3 butadiene can be accelerated by the supplementation of glutathione (reduced) either oral, intravenous, transdermal, or its precursor N-acetyl cysteine(NAC).

NADB is a metabolite of 1,3 butadiene, which is evident of exposure to synthetic rubber such as tires. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin.

N-Acetyl(3,4-dihydroxybutyl) cysteine (NADB) is a result of the exposure to 1,3 butadiene and NABD is the major metabolite. This metabolite is evidence of exposure to synthetic rubber such as tires. The primary route of exposure is inhalation. Some exposure may occur through ingestion of contaminated food or water or through dermal contact. Newer playgrounds and athletic fields are now made with ground up tires, which may lead to increased exposure for children. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease.

Organize and understand all your lab results

Start organizing — $15/mo →

For Health Professionals Healthmatters Pro Multiple clients’ results in one dashboard. See Pro plans →

N-acetyl(3,4-dihydroxybutyl)cysteine (NADB)

Every lab result you’ve ever had, charted and explained.

Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.

Start with my report →

Clinical Sources & References

All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.

Article Review Log

Written by Healthmatters Editorial Team

Organize and understand all your lab results

Start organizing — $15/mo →

For Health Professionals Healthmatters Pro Multiple clients’ results in one dashboard. See Pro plans →

Healthmatters Lifetime Plan

Pay $250. Track your health forever

One payment. No renewals. Yours for life.

10,000+ biomarkers explained · trends over time

See other plans →

Secure checkout via Stripe · GDPR & HIPAA

We accept results from any lab

LabCorp Quest Diagnostics Genova Diagnostics DUTCH Test Doctor's Data Vibrant America ZRT Laboratory Cyrex Labs + any other lab

What members are saying

★★★★★ 10,000+ happy members

★★★★★

"Watching my numbers move over the years — instead of forgetting last time's results — completely changed how I manage my health."

Daniel

Member since 2022

★★★★★

"Living across several countries made keeping my lab results organized a real challenge. Healthmatters brought my results from the USA, Spain, and Germany together — 20 years of history, with long-term trends instead of scattered reports."

Ben

Member since 2021 · tracks across countries

★★★★★

"Standard lab ranges are too wide for how I practice — 'normal' isn't optimal. I set my own bands, so a client sees yellow before a marker goes officially out of range. That's the conversation I want to be having."

Dr. Alexandra

Functional medicine · 6 yrs on Pro