A healthy result should fall into the range 0 - 1 µg/g creatinine.
N-acetyl (2-cyanoethyl) cysteine (NACE) is a result of the exposure to acrylonitrile and NACE is the major metabolite. Acrylonitrile is a colorless liquid with a pungent odor. It is used in the production of acrylic fibers, resins, and rubber. Use of any of these products could lead to exposure to acrylonitrile. Smoking tobacco and cigarettes is another potential exposure. Exposure to acrylonitrile can lead to headaches, nausea, dizziness, fatigue, and chest pains. The European Union has classified acrylonitrile as a carcinogen.
NACE is a metabolite of acrylonitrile, which is used in the production of acrylic fibers, resins, and rubber.
Acrylonitrile is metabolized by the cytochrome P450s and then conjugated to glutathione. Elimination of acrylonitrile can be accelerated by the supplementation of glutathione (reduced) either oral, intravenous, transdermal, or its precursor N-acetyl cysteine(NAC).
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