Borrelia burgdorferi VlsE1 - IgG

Optimal Result: 0 - 10 Units.

Easy Interpretation of your Lyme results:


CDC Criteria - 1 Positive - VlsE1, C6 peptide, or WCS AND 2 of the following 3 antigens are positive -- 23-25, 39, 41

Alternative Criteria - 1 Positive/Borderline - VlsE1, C6 peptide, or WCS AND 2 of the following 6 antigens are positive/borderline -- 23-25, 31, 34, 39, 41, 83-93


CDC Criteria - 1 Positive - VlsE1, C6 peptide, or WCS AND 5 of the following 10 antigens are positive -- 18, 23-25, 28, 30, 39, 41, 45, 58, 66, 83-93

Alternative Criteria - 1 Positive/Borderline - VlsE1, C6 peptide, or WCS AND 2 of the following 12 antigens are positive/borderline -- 18, 23-25, 28, 30, 31, 34, 39, 41, 45, 58, 66, 83-93

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

Variable major protein like sequence E1 protein (VlsE1) is a borrelial surface protein which is the most sensitive protein for IgG antibody detection in all stages of Lyme disease. It is particularly valuable for diagnosis of Lyme disease during early manifestations (EM and acute neuroborreliosis).

What does it mean if your Borrelia burgdorferi VlsE1 - IgG result is too high?

CDC criteria Lyme IgG is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is positive and any five of the following ten antigens are positive:










and 83-93kDa.

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