Easy Interpretation of your Lyme results:
IgM
CDC Criteria - 1 Positive - VlsE1, C6 peptide, or WCS AND 2 of the following 3 antigens are positive -- 23-25, 39, 41
Alternative Criteria - 1 Positive/Borderline - VlsE1, C6 peptide, or WCS AND 2 of the following 6 antigens are positive/borderline -- 23-25, 31, 34, 39, 41, 83-93
IgG
CDC Criteria - 1 Positive - VlsE1, C6 peptide, or WCS AND 5 of the following 10 antigens are positive -- 18, 23-25, 28, 30, 39, 41, 45, 58, 66, 83-93
Alternative Criteria - 1 Positive/Borderline - VlsE1, C6 peptide, or WCS AND 2 of the following 12 antigens are positive/borderline -- 18, 23-25, 28, 30, 31, 34, 39, 41, 45, 58, 66, 83-93
Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.
Variable major protein like sequence E1 protein (VlsE1) is a borrelial surface protein which is the most sensitive protein for IgG antibody detection in all stages of Lyme disease. It is particularly valuable for diagnosis of Lyme disease during early manifestations (EM and acute neuroborreliosis).
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CDC criteria Lyme IgG is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is positive and any five of the following ten antigens are positive:
18kDa,
23-25kDa,
28kDa,
30kDa,
39kDa,
41kDa,
45kDa,
58kDa,
66kDa
and 83-93kDa.
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Anaplasma phagocytophilum Msp5 - IgG, Babesia microti WCS - IgG, Bartonella henselae SucB - IgM, Bartonella vinsonii - IgM, Borrelia afzelii DbpA - IgG, Borrelia afzelii OspA - IgG, Borrelia afzelii p100 - IgG, Borrelia burgdorferi 297 strain WCS - IgM, Borrelia burgdorferi C6 peptide - IgM, Borrelia burgdorferi p23-25 (OspC), Borrelia burgdorferi p31 (OspA) - IgG, Borrelia burgdorferi p31 (OspA) - IgM, Borrelia burgdorferi p34 (OspB) - IgG, Borrelia burgdorferi p66 - IgG, Borrelia burgdorferi p66 - IgM, Borrelia burgdorferi VlsE1 - IgG, Borrelia yangtzensis - IgG, Borrella turicatae - IgM, HHV-7 - IgG, Parovirus B19 VLP VP1/Vp2 Co Capsid - IgG, Rickettsia typhi Surface antigen - IgG, Toxoplasma gondii MIC3 - IgG