Borrelia burgdorferi p66 - IgG

Optimal Result: 0 - 10 Units.

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

B. burgdorferi p66 is an outer membrane spanning protein Oms66. It is proven to be an integral membrane porin because liposome-reconstituted P66 displayed channel-forming activity in planar lipid bilayer assays. P66 has also been shown to function as an adhesin that binds the mammalian cell receptors, B3 chain and B1 chain integrins.

What does it mean if your Borrelia burgdorferi p66 - IgG result is too high?

CDC criteria Lyme IgG is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is positive and any five of the following ten antigens are positive:

18kDa,

23-25kDa,

28kDa,

30kDa,

39kDa,

41kDa,

45kDa,

58kDa,

66kDa

and 83-93kDa.

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