Immunoserology of Lyme
Serum
Performed by: Immunosciences Lab, Inc.
What is Immunoserology of Lyme?
The Immunoserology of Lyme panel is a serum-based test that uses advanced ELISA methodology to detect both active and chronic Lyme disease, including complications such as Lyme arthritis and neuroborreliosis.
This panel measures IgM and IgG antibodies against Borrelia burgdorferi and its subspecies (B. afzelii, B. garinii, B. miyamotoi), as well as potential tick-borne co-infections like Babesia, Bartonella, and Ehrlichia. By analyzing antibodies to multiple Borrelia antigens—such as Outer Surface Proteins (OspA, OspB, OspC, OspE), Variable Major Protein (VMP), and Leukocyte Function Associated Antigen (LFA)—the test provides a more precise and reliable diagnosis than standard Lyme assays.
Why Accurate Lyme Testing Matters
Lyme disease often mimics autoimmune or neurological conditions, making misdiagnosis common.
-
False positives can lead to unnecessary treatment and side effects.
-
False negatives may delay care, increasing the risk of arthritis, meningitis, or long-term neurological complications.
By combining cultured Borrelia antigens with proteins expressed in vivo, this immunoserology panel improves diagnostic accuracy and helps distinguish Lyme disease from other inflammatory conditions.
When This Panel is Recommended
This test may be considered for patients with:
-
History of a tick bite or erythema migrans (rash)
-
Unexplained autoimmune-like symptoms (lupus, rheumatoid arthritis, psoriatic arthritis)
-
Neurological issues (cranial neuritis, meningitis, memory problems, nerve pain)
-
Chronic joint pain or arthritis (Lyme arthritis, chronic synovitis)
-
Immune dysfunction or chronic fatigue
Summary
Lyme borreliosis is an inflammatory disease affecting multiple organ systems—including the skin, joints, nervous system, heart, and immune system. The Immunoserology of Lyme panel offers a comprehensive and patented ELISA approach to detecting Borrelia infections and related co-infections, guiding earlier and more effective treatment decisions.
Show more
Biomarkers included in this panel:
IgG B. afzelii
The IgG Borrelia afzelii test measures antibodies against Borrelia afzelii, one of the main bacterial species that cause Lyme disease in Europe and Asia. Unlike Borrelia burgdorferi (more common in North America), B. afzelii is especially associated
Learn moreThe IgG Borrelia burgdorferi sensu stricto (s.s.) test measures antibodies against the primary species of Borrelia that causes Lyme disease in North America and parts of Europe. This species is strongly linked to arthritis, neurological symptoms, and
Learn moreIgG B. burgdorferi AG
The IgG Borrelia burgdorferi Antigen (Ag) test measures long-term antibodies against antigens of Borrelia burgdorferi, the main bacterium responsible for Lyme disease, particularly in North America. Unlike species-specific tests that focus on one str
Learn moreIgG B. garinii
The IgG Borrelia garinii test detects antibodies against Borrelia garinii, one of the main bacterial species in the Borrelia burgdorferi sensu lato complex that causes Lyme disease, particularly in Europe and Asia. This strain is strongly linked with
Learn moreIgG B. miyamotoi
The IgG Borrelia miyamotoi test detects antibodies against Borrelia miyamotoi, a tick-borne bacterium closely related to Lyme disease pathogens but classified as a relapsing fever Borrelia species. Unlike Borrelia burgdorferi sensu lato (which causes
Learn moreIgG Babesia
The IgG Babesia test measures antibodies against Babesia species, a group of parasites transmitted by ticks that can cause babesiosis, a malaria-like illness. Babesia microti is the most common species in North America, while Babesia divergens and ot
Learn moreIgG Bartonella
The IgG Bartonella test measures antibodies against Bartonella species, a group of bacteria transmitted by ticks, fleas, or scratches from infected animals (especially cats). Bartonella henselae and Bartonella quintana are the most common human patho
Learn moreIgG Ehrlichia
The IgG Ehrlichia test measures antibodies against Ehrlichia species, bacteria transmitted by ticks that cause ehrlichiosis, a potentially serious tick-borne illness. The two main human pathogens are Ehrlichia chaffeensis (human monocytic ehrlichiosi
Learn moreIgG Immunodominant P. C6
The IgG Immunodominant Peptide C6 (P. C6) test detects antibodies against a highly conserved region of the VlsE protein from Borrelia burgdorferi, the main bacterium that causes Lyme disease. The C6 peptide is considered an immunodominant epitope&mda
Learn moreIgG LFA Antigen + CK10
The IgG LFA Antigen + CK10 test evaluates long-term antibody responses to both Borrelia antigens (using a lateral flow assay, or LFA) and Cytokeratin 10 (CK10), a structural protein found in epithelial tissues such as the skin. This combined test hel
Learn moreIgG Outer Surface P. A+C
The IgG Outer Surface Proteins A and C (OspA & OspC) test is a blood test that measures your immune system’s production of IgG antibodies against specific proteins on the surface of Borrelia burgdorferi, the bacteri
Learn moreIgG Outer Surface P. E
The IgG OspE test measures antibodies against Outer Surface Protein E (OspE) of Borrelia burgdorferi, one of the proteins that help the bacterium evade the immune system and persist in the body. OspE belongs to the Erp (OspE-related proteins) family,
Learn moreThe IgG VmpE test measures antibodies against Variable Major Protein E (VmpE), a surface protein produced by Borrelia burgdorferi, the bacterium that causes Lyme disease. VmpE belongs to a family of variable major proteins (Vmps) that the bacteria ca
Learn moreIgM B. afzelii
IgM B. afzelii measures early antibodies against Borrelia afzelii, a major cause of Lyme disease in Europe and Asia. Unlike B. burgdorferi sensu stricto, which dominates in North America, B. afzelii is strongly linked to skin-related forms of Lyme bo
Learn moreThe IgM B. burgdorferi sensu stricto test helps detect early Lyme disease by measuring IgM antibodies, which the body produces soon after a tick bite. A positive result may point to a recent infection, but it isn’t always proof of act
Learn moreIgM B. burgdorferi AG
The IgM B. burgdorferi Antigen (AG) test measures early antibodies against a broad set of Borrelia burgdorferi proteins, making it a sensitive marker for detecting early Lyme disease. IgM antibodies typically appear within 1&
Learn moreIgM B. garinii
The IgM B. garinii test detects early antibodies against Borrelia garinii, a subspecies within the Borrelia burgdorferi sensu lato complex that is especially common in Europe and Asia and strongly associated with neurological
Learn moreIgM B. miyamotoi
The IgM B. miyamotoi test detects early antibodies against Borrelia miyamotoi, a relapsing fever–type spirochete transmitted by the same Ixodes ticks that spread Lyme disease. Unlike classical Lyme borreliosis, B.
Learn moreIgM Babesia
The IgM Babesia test measures early antibodies against Babesia species, tick-borne protozoan parasites that invade red blood cells and can cause babesiosis, a malaria-like illness. In North America, Babesia microti
Learn moreIgM Bartonella
The IgM Bartonella test detects early antibodies against Bartonella species, a group of bacteria transmitted by ticks, fleas, lice, or scratches from infected animals (especially cats). The most common human pathogens are Bartonella henselae and Bart
Learn moreIgM Ehrlichia
The IgM Ehrlichia test detects early antibodies to Ehrlichia species, tick-borne bacteria that invade white blood cells and cause ehrlichiosis, most often due to E. chaffeensis (human monocytic ehrlichiosis) or
Learn moreIgM Immunodominant P. C6
The IgM Immunodominant C6 test measures early antibodies against the conserved C6 peptide of VlsE, a key surface protein of Borrelia burgdorferi sensu lato. Because the IR6 region of VlsE is highly conserved across major Lyme-causing s
Learn moreIgM LFA Antigen + CK10
The IgM LFA Antigen + CK10 test measures two important parts of the immune system. The IgM portion looks for the body’s early-response antibodies, which usually appear soon after an infection begins, such as from a virus, bacteri
Learn moreIgM Outer Surface P. A+C
IgM OspA + OspC The IgM OspA + OspC test helps detect an early immune response to Borrelia burgdorferi, the bacteria that cause Lyme disease. It looks for IgM antibodies against two important surface proteins: OspC (Outer Surface Protein
Learn moreIgM Outer Surface P. E
The IgM OspE test detects early antibodies against Outer Surface Protein E (OspE) of Borrelia burgdorferi, the bacterium responsible for Lyme disease. OspE belongs to the Erp (OspE-related proteins) family, which helps Borrelia survive in the human b
Learn moreThe IgM Variable Major Protein E (VmpE) test detects early antibodies against a surface protein that Borrelia burgdorferi—the bacteria responsible for Lyme disease—uses to survive through antigenic variation. VmpE can repeatedly alter its
Learn more