IgG Outer Surface P. E

Serum

Optimal Result: 0 - 0.81 index.

Immunoserology of Lyme Immunosciences Lab, Inc.

From Healthmatters.io Team

Lab Results Explained and Tracked

The IgG OspE test measures antibodies against Outer Surface Protein E (OspE) of Borrelia burgdorferi, one of the proteins that help the bacterium evade the immune system and persist in the body. OspE belongs to the Erp (OspE-related proteins) family, which plays a key role in protecting Borrelia from complement-mediated killing by binding to host factor H.

What IgG OspE Means

IgG antibodies against OspE typically develop weeks to months after infection and may remain detectable long after exposure.
A positive IgG OspE result indicates past immune recognition of Borrelia, which can support the diagnosis of later or persistent Lyme disease.
Because OspE helps Borrelia survive in the bloodstream, IgG detection may be especially relevant in patients with disseminated or chronic forms of infection.

Clinical Importance

Testing for IgG OspE may be most useful in patients with:

Persistent or late-stage Lyme symptoms such as arthritis, fatigue, or neurological complaints
Evidence of Borrelia dissemination, where immune evasion mechanisms are important
Chronic or relapsing illness following a history of tick exposure in endemic regions
Suspected co-infections, where broader immune profiling improves diagnostic accuracy

Patient Takeaway

A positive IgG OspE result suggests your immune system has previously recognized this Borrelia surface protein, pointing to past or ongoing exposure. However, IgG antibodies can remain in the body long after the initial infection, so the result does not confirm whether the infection is still active.

Your healthcare provider will interpret the result alongside your symptoms, clinical history, and additional Lyme disease markers (such as OspC, OspA, or VlsE/C6).

If your IgG OspE result is equivocal (borderline), antibody levels are near the cutoff and not clearly positive or negative. In such cases, repeat or confirmatory testing may be recommended.

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IgG Outer Surface P. E

What IgG OspE Means

Clinical Importance

Patient Takeaway

All Your Lab Results. One Simple Dashboard.

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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