IgM Immunodominant P. C6

Serum

Optimal Result: 0 - 0.81 index.

Immunoserology of Lyme Immunosciences Lab, Inc.

From Healthmatters.io Team

Lab Results Explained and Tracked

Overview

The IgM Immunodominant C6 (IR6) test detects early antibodies against the conserved C6 peptide, a 26–amino acid sequence from the invariable region (IR6) of VlsE, the variable surface antigen in Borrelia burgdorferi sensu lato. While VlsE undergoes domain variation to evade the immune system, the IR6 region remains highly conserved across Lyme-causing subspecies (B. burgdorferi sensu stricto, B. afzelii, B. garinii). This conservation makes C6-based assays valuable broad-spectrum markers in Lyme serology.

Why IgM to C6 Matters

Early signal of infection: IgM antibodies are the first to rise after exposure, and anti-C6 IgM can appear within 1–3 weeks of a tick bite, indicating early or recent infection.
Cross-subspp coverage: Because the C6 epitope is conserved, the assay can detect immune responses across diverse Borrelia subspecies in North America, Europe, and parts of Asia.
Diagnostic utility: Evaluations of C6 ELISA show high sensitivity in acute infection (increasing into convalescence) and strong specificity, supporting its rule-in value when combined with compatible symptoms and exposure risk.

Clinical Significance

A positive IgM C6 suggests an early immune response to Lyme borreliosis, particularly valuable for patients with:

Early localized or disseminated disease: erythema migrans, fever, headache, myalgia, fatigue
Neurological presentations: meningitis, cranial neuritis, radiculoneuritis
Musculoskeletal involvement: migratory arthralgias or evolving arthritis

Because C6 can be measured quantitatively, serial testing may support follow-up, though antibody kinetics vary and serology should not be used alone to monitor treatment response.

Limitations and Interpretation Caveats

Timing: IgM is most informative within the first month; isolated IgM beyond 6–8 weeks without IgG warrants caution (may reflect non-specific reactivity or past exposure).
Cross-reactivity: Though designed for specificity, occasional reactivity occurs (e.g., autoimmune triggers or other Borrelia species). Notably, C6 reactivity has been described in Borrelia miyamotoi (a relapsing fever–group spirochete).
No subspecies resolution: C6 reflects pan-Borrelia exposure but does not identify the infecting strain or stage of disease.
Clinical context required: A positive C6 IgM alone does not confirm active Lyme. Integration with exposure history, symptoms, exam findings, confirmatory markers (VlsE/whole-cell EIAs, immunoblots, Osp proteins, subspecies-specific antigens), and co-infection assessment (Babesia, Anaplasma/Ehrlichia, Bartonella) is essential.

Role in Modern Lyme Testing

C6 assays are increasingly used in modified two-tier Lyme testing algorithms, valued for their broad coverage and strong analytic performance. In multi-antigen ELISA panels, IgM C6 complements other markers such as OspC, VlsE/DbpA, and subspecies-specific assays, enhancing early detection while maintaining high specificity across the clinical spectrum.

Summary

The IgM Immunodominant C6 marker is a conserved, early-phase Lyme serology tool that captures recent immune responses across major Borrelia subspecies. It offers strong diagnostic value in acute disease but requires careful interpretation, particularly when IgM is isolated or when cross-reactivity is considered. Most powerful when paired with compatible symptoms, exposure history, and complementary serology, IgM C6 serves as a core element of modern multi-antigen Lyme testing strategies.

Lab Results Explained and Tracked

All Your Lab Results.
One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.

Cancel or upgrade anytime

Article Review & Sources

All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We're committed to accuracy and transparency — see our editorial policy for details.

Laboratories

Bring All Your Lab Results Together — In One Place

We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.

Pricing Table

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Choose the plan that fits you — and turn scattered lab reports into clear insights you can finally use.

Pick a plan that fits you — and turn scattered lab reports into clarity.

Personal plans

Professional plan

$79/ year

Advanced Plan

Access your lab reports, explanations, and tracking tools.

Import lab results from any provider
Track all results with visual tools
Customize your reference ranges
Export your full lab history anytime
Share results securely with anyone
Receive 5 reports entered for you
Cancel or upgrade anytime

$250/ once

Unlimited Account

Pay once, access everything—no monthly fees, no limits.

Import lab results from any provider
Track all results with visual tools
Customize your reference ranges
Export your full lab history anytime
Share results securely with anyone
Receive 10 reports entered for you
No subscriptions. No extra fees.

Professional plan

$45/ month

Pro Monthly

Designed for professionals managing their clients' lab reports

Import lab results from any provider
Track lab results for multiple clients
Customize reference ranges per client
Export lab histories and reports
Share results and reports with clients
Invite clients to their accounts
Begin with first report entered by us
Cancel or upgrade anytime

About membership

What's included in a Healthmatters membership

Import Lab Results from Any Source

Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.

Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.

See Your Health Timeline

Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.

Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.

Understand What Your Results Mean

Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.

Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Advanced plan and Unlimited plan members.

Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.

Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.

Visualize Your Results

View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.

See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.

Export Your Complete Lab History in a Single File Export Your Complete Lab History

After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.

After collecting lab results from different providers, you can download your entire history combined into a single file.

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Advanced plan members receive five reports entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.

Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.

Securely Share With Anyone You Trust

Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.

Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.

Discover

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.

Anthony

Unlimited Plan Member since 2021

What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!

Karin

Advanced Plan Member since 2020

As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!

Paul

Healthmatters Pro Member since 2024

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

IgM Immunodominant P. C6

Overview

Why IgM to C6 Matters

Clinical Significance

Limitations and Interpretation Caveats

Role in Modern Lyme Testing

Summary

All Your Lab Results. One Simple Dashboard.

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

What Healthmatters Members Are Saying

Use promo code to save 10% off any plan.

We implement proven measures to keep your data safe.

All Your Lab Results.
One Simple Dashboard.

All Your Lab Results.
One Simple Dashboard.