DUTCH

Estradiol (E2) (male)

Optimal Result: 0.5 - 2.2 ng/mg.

Estradiol is the main "female" hormone. The full name is 17-beta-Estradiol, which is also available in several medications for ERT therapy. Current research indicates that, in some people, this hormone may play a role in the loss of bone density, prevents male bodies from clearing DHT out of the prostate gland, and can stimulate estrogen-sensitive tumor growth (if estrogen-sensitive cancer cells are already present).

Women synthesize most of their estrogen in their ovaries and other reproductive tissues.

Since men lack this female anatomy, they need to produce estrogen through a process involving an enzyme called aromatase that transforms testosterone into estradiol.

Aging men sometimes have too much aromatase activity, which causes their testosterone to convert to excess estradiol. This results in depletionof vital testosterone while spiking estradiol to unsafe ranges.

What does it mean if your Estradiol (E2) (male) result is too low?

 

What does it mean if your Estradiol (E2) (male) result is too high?

Causes:

Common:

- Testosterone supplementation (>75 mg/day)

Intermediate:

- Excessive aromatase activity (may be associated with obesity)

Uncommon:

- DHEA supplementation

- Testicular, adrenal or hepatic tumors (may be associated with gynecomastia)

- Hepatic cirrhosis

The most common symptoms of high estrogen in men include these:

- Sexual dysfunction (low libido, decreased morning erections, decreased erectile function)

- Enlarged breasts

- Lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH)[2]

- Increased abdominal fat (can also be a symptom of low estrogen)

- Feeling tired

- Loss of muscle mass

- Emotional disturbances, especially depression

- Type 2 diabetes

Possible treatment:

To help lower your estrogen levels, your doctor might recommend changes to your eating habits. For example, they might encourage you to eat a low-fat and high-fiber diet that includes:

- cruciferous vegetables

- mushrooms

- red grapes

- flax seeds

- green tea

- pomegranate

Your doctor might also encourage you to lose excess weight and/or prescribe medication or recommend surgery.

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