A healthy result should fall into the range 0 - 5.9 ng/mg.
2-OH-E1 is considered a ‘good estrogen’ and it does not stimulate cell growth. It can block the action of stronger, potentially carcinogenic estrogens. When it is methylated to 2-Me-E1 it is cancer protective.
2-Hydroxyestrone is an endogenous biomarker and major urinary metabolite of estrone and estradiol. Along with 16α-Hydroxyestrone, 2-Hydroxyestrone is used as an indicator for increased risk of breast cancer.
This metabolite of Estrone is considered protective. A comparison with 2-Methoxyestrone, its Phase II liver metabolite, may help with assessing adequacy of methylation processes.
The 2:16alpha-Hydroxyestrone ratio appears from the literature to be an important gauge of estrogen metabolism. In general, the higher the ratio, the less association there is with estrogen-dependent diseases such as breast cancer and lupus, and the more likely the person has a beneficial hormone metabolism. A 2:16alpha-hydroxyestrone ratio in serum greater than 0.4 is generally thought to be beneficial. There are numerous modifiers of this value, most of which induce changes in the level of 2-OHE1. These include intake of indole-3-carbinols from cruciferous vegetables, flaxseed, soy, omega-3 fatty acids, and vigorous exercise. All are shown to improve the levels of 2-OHE1 in most individuals. It is to be emphasized that some individuals in clinical studies have exhibited a paradoxical response to treatments that would typically raise the 2-OHE1 levels. Therefore, follow-up testing after treatment is strongly suggested. There may be an increased likelihood of osteoporosis with excessive 2-OHE1 production. It is important to note that the ideal upper limit of 2-OHE1 is not apparent from the existing literature. Attention to bone loss processes in the urine is perhaps warranted in individuals with a very high 2:16alpha-hydroxyestrone ratio.
References:
insert the value from you 2-OH-E1 (male) test result.
High levels of the “good estrogen” are typically considered beneficial; however, when coupled with a low 2-OMe-E1, it may indicate poor methylation activity.
If both 2-OH-E1 and 16a-OHE1 are high, then total estrogen load may be high. Consider methods to better clear the estrogens from the body.
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16-OH-E1, 16-OH-E1 (male), 16-OH-E1 Postmenopausal, 2-Methoxy-E1, 2-Methoxy-E1 (male), 2-Methoxy-E1 Postmenopausal, 2-Methoxy-E2, 2-Methoxy-E2 Postmenopausal, 2-OH-E1, 2-OH-E1 (male), 2-OH-E1 Postmenopausal, 2-OH-E2, 2-OH-E2 Postmenopausal, 24hr Free Cortisol, 24hr Free Cortisone, 4-OH-E1, 4-OH-E1 (male), 4-OH-E1 Postmenopausal, 4-OH-E2, 4-OH-E2 Postmenopausal, 5-Hydroxyindoleacetate (5HIAA), 5a-Androstanediol, 5a-Androstanediol (male), 5a-DHT, 5a-DHT (male), 5b-Androstanediol, 5b-Androstanediol (male), 8-OHdG (Waking), a-Pregnanediol (luteal range), a-Pregnanediol (male), a-Pregnanediol (oral progesterone range), a-Pregnanediol (postmenopausal range), a-Tetrahydrocortisol (a-THF), a-Tetrahydrocortisol (a-THF) (male), Androsterone, Androsterone (male), b-Pregnanediol (luteal range), b-Pregnanediol (male), b-Pregnanediol (oral progesterone range), b-Pregnanediol (postmenopausal range), b-Tetrahydrocortisol (b-THF), b-Tetrahydrocortisol (b-THF) (male), b-Tetrahydrocortisone (b-THE), b-Tetrahydrocortisone (b-THE) (male), Cortisol A (Waking), Cortisol B (Morning), Cortisol C (Afternoon), Cortisol D (Night), Cortisone A (Waking), Cortisone B (Morning), Cortisone C (Afternoon), Cortisone D (Night), Creatinine A (Waking), Creatinine B (Morning), Creatinine C (Afternoon), Creatinine D (Night), DHEA-S (Urine), DHEA-S (Urine) (male), Epi-Testosterone, Epi-Testosterone (male), Estradiol (E2), Estradiol (E2) (male), Estradiol (E2) Postmenopausal, Estriol (E3), Estriol (E3) (male), Estriol (E3) Postmenopausal, Estrone (E1), Estrone (E1) Postmenopausal, Estrone(E1) (male), Etiocholanolone, Etiocholanolone (male), Homovanillate (HVA) (DUTCH), Kynurenate, Melatonin (Waking), Metabolized Cortisol (THF+THE), Metabolized Cortisol (THF+THE) (male), Methylmalonate (MMA) (DUTCH), Progesterone, Pyroglutamate, Saliva Cortisol - Afternoon, Saliva Cortisol - Night, Saliva Cortisol - W+30 min., Saliva Cortisol - W+60 min., Saliva Cortisol - Waking, Saliva Cortisol Total, Saliva Cortisone - Afternoon, Saliva Cortisone - Night, Saliva Cortisone - W+30 min, Saliva Cortisone - W+60 min., Saliva Cortisone - Waking, Saliva Cortisone Total, Testosterone (DUTCH), Testosterone (DUTCH) (male), Total DHEA Production, Total Estrogen, Total Estrogen (male), Total Estrogen Postmenopausal, Vanilmandelate (VMA), Xanthurenate
