A healthy result should fall into the range 0 - 5.9 ng/mg.
2-OH-E1 is considered a ‘good estrogen’ and it does not stimulate cell growth. It can block the action of stronger, potentially carcinogenic estrogens. When it is methylated to 2-Me-E1 it is cancer protective.
2-Hydroxyestrone is an endogenous biomarker and major urinary metabolite of estrone and estradiol. Along with 16α-Hydroxyestrone, 2-Hydroxyestrone is used as an indicator for increased risk of breast cancer.
This metabolite of Estrone is considered protective. A comparison with 2-Methoxyestrone, its Phase II liver metabolite, may help with assessing adequacy of methylation processes.
The 2:16alpha-Hydroxyestrone ratio appears from the literature to be an important gauge of estrogen metabolism. In general, the higher the ratio, the less association there is with estrogen-dependent diseases such as breast cancer and lupus, and the more likely the person has a beneficial hormone metabolism. A 2:16alpha-hydroxyestrone ratio in serum greater than 0.4 is generally thought to be beneficial. There are numerous modifiers of this value, most of which induce changes in the level of 2-OHE1. These include intake of indole-3-carbinols from cruciferous vegetables, flaxseed, soy, omega-3 fatty acids, and vigorous exercise. All are shown to improve the levels of 2-OHE1 in most individuals. It is to be emphasized that some individuals in clinical studies have exhibited a paradoxical response to treatments that would typically raise the 2-OHE1 levels. Therefore, follow-up testing after treatment is strongly suggested. There may be an increased likelihood of osteoporosis with excessive 2-OHE1 production. It is important to note that the ideal upper limit of 2-OHE1 is not apparent from the existing literature. Attention to bone loss processes in the urine is perhaps warranted in individuals with a very high 2:16alpha-hydroxyestrone ratio.
References:
insert the value from you 2-OH-E1 (male) test result.
High levels of the “good estrogen” are typically considered beneficial; however, when coupled with a low 2-OMe-E1, it may indicate poor methylation activity.
If both 2-OH-E1 and 16a-OHE1 are high, then total estrogen load may be high. Consider methods to better clear the estrogens from the body.
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16-OH-E1, 16-OH-E1 (male), 2-Methoxy-E1, 2-Methoxy-E1 (male), 2-Methoxy-E2, 2-OH-E1, 2-OH-E1 (male), 2-OH-E2, 24hr Free Cortisol, 24hr Free Cortisone, 4-OH-E1, 4-OH-E1 (male), 4-OH-E2, 5-Hydroxyindoleacetate (5HIAA), 5a-Androstanediol, 5a-Androstanediol (male), 5a-DHT, 5a-DHT (male), 5b-Androstanediol, 5b-Androstanediol (male), 8-OHdG (Waking), a-Pregnanediol (luteal range), a-Pregnanediol (male), a-Pregnanediol (oral progesterone range), a-Pregnanediol (postmenopausal range), a-Tetrahydrocortisol (a-THF), a-Tetrahydrocortisol (a-THF) (male), Androsterone, Androsterone (male), b-Pregnanediol (luteal range), b-Pregnanediol (male), b-Pregnanediol (oral progesterone range), b-Pregnanediol (postmenopausal range), b-Tetrahydrocortisol (b-THF), b-Tetrahydrocortisol (b-THF) (male), b-Tetrahydrocortisone (b-THE), b-Tetrahydrocortisone (b-THE) (male), Cortisol A (Waking), Cortisol B (Morning), Cortisol C (Afternoon), Cortisol D (Night), Cortisone A (Waking), Cortisone B (Morning), Cortisone C (Afternoon), Cortisone D (Night), Creatinine A (Waking), Creatinine B (Morning), Creatinine C (Afternoon), Creatinine D (Night), DHEA-S (Urine), DHEA-S (Urine) (male), Epi-Testosterone, Epi-Testosterone (male), Estradiol(E2), Estradiol(E2) (male), Estriol(E3), Estriol(E3) (male), Estrone(E1), Estrone(E1) (male), Etiocholanolone, Etiocholanolone (male), Homovanillate (HVA) (DUTCH), Melatonin (Waking), Metabolized Cortisol (THF+THE), Metabolized Cortisol (THF+THE) (male), Methylmalonate (MMA) (DUTCH), Progesterone (Urine), Pyroglutamate, Saliva Cortisol - Afternoon, Saliva Cortisol - Night, Saliva Cortisol - W+30 min., Saliva Cortisol - W+60 min., Saliva Cortisol - Waking, Saliva Cortisol Total (male), Saliva Cortisone - Afternoon, Saliva Cortisone - Night, Saliva Cortisone - W+30 min, Saliva Cortisone - W+60 min., Saliva Cortisone - Waking, Saliva Cortisone Total, Testosterone (DUTCH), Testosterone (DUTCH) (male), Total DHEA Production, Total Estrogen, Total Estrogen (male), Vanilmandelate (VMA), Xanthurenate
