The 2-Methoxy Estrogens are considered to be protective. Low levels are usually a reflection of overall low estrogens and may be improved with supplemental estrogen. Metabolized from 2-OH E1. A comparison of 2-MeOH E1 with 2-OH E1 allows insight into methylation pathways. If 2-MeOH E1 value is at least 25% of 2-OH E1 value, methylation is probably adequate. If <25% consider adding methyl donors.
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