Ribosomal P Antibody

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Ribosomal P Antibody (aka Anti-ribosomal P or anti-Rib-P antibody) is a specific serological marker for systemic lupus erythematosus (SLE).

Autoantibodies to ribosomal P proteins (anti-rib P) are specific serological markers for systemic lupus erythematosus (SLE) and are associated with liver involvement in this disease. The similarity in autoimmune background between autoimmune hepatitis (AIH) and SLE-associated hepatitis raises the possibility that anti-rib P antibodies might also have relevance in AIH.

Anti-Rib-P is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against ribosomal P proteins in human serum or plasma. They recognize a common epitope of the three phosphoproteins P0, P1 and P2 of the 60S subunit of the ribosomal complex.

Like anti-nuclear antibodies (ANA), anti-cytoplasmic antibodies play a role in rheumatic disease. Of these, the anti-ribosomal antibodies (ARA) are the best characterized. Autoantibodies against ribosomal P-proteins are highly specific markers for diagnostics of systemic lupus erythematosus, because they rarely occur in other autoimmune diseases. ARA are found in only about 10 % of randomly selected SLE patients, but are detected in up to 40 % of SLE patients whose disease status is active. Anti-Rib-P detection is recommended in cases of suspected SLE when antibodies against Sm antigens and double-stranded DNA are absent.


Calich AL, Viana VS, Cancado E, Tustumi F, Terrabuio DR, Leon EP, Silva CA, Borba EF, Bonfa E. Anti-ribosomal P protein: a novel antibody in autoimmune hepatitis. Liver Int. 2013 Jul;33(6):909-13. doi: 10.1111/liv.12155. Epub 2013 Mar 24. PMID: 23522300. [L]

What does it mean if your Ribosomal P Antibody result is too high?

Ribosomal P antibodies are found in 10% to 20% of patients with systemic lupus erythematosus (SLE) and are purported to be associated with lupus psychosis.

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