Anti-Centromere Antibodies (Anti-Centromere Ab) detected by Indirect Immunofluorescence Assay (IFA) at RDL (Reference Diagnostic Laboratories) are essential diagnostic markers associated with autoimmune disorders, particularly limited cutaneous scleroderma and CREST syndrome.
These antibodies are directed against specific components of the centromere, a region of the chromosome. Anti-Centromere Abs are found in a significant proportion of patients with limited systemic sclerosis and CREST syndrome, providing valuable insights into the diagnosis of these conditions.
They can also be detected in a smaller percentage of patients with diffuse systemic sclerosis and primary biliary cirrhosis. The IFA method employed at RDL allows for the detection of these antibodies by assessing their distinctive pattern of fine-speckled nuclear staining on cell substrates. While the presence of Anti-Centromere Antibodies is not exclusive to these conditions, their detection plays a crucial role in identifying and diagnosing autoimmune disorders, aiding in the early initiation of appropriate medical management and treatment.
- The most common setting for finding anti-centromere antibodies is in patients with a limited cutaneous form of scleroderma. Anti-centromere abs are found in 22% of patients with systemic sclerosis and in 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals.
- Anti-centromere abs are found in 46% of patients with Limited Systemic Sclerosis and 11% in Diffuse Systemic Sclerosis, as well as 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals. The antibodies are associated with CREST syndrome.
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