Scl-70 antibody is seen in 20% of people with scleroderma (also known as systemic sclerosis), and in some people with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia).
These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.
Negative results do not necessarily rule out the presence of SSc. If clinical suspicion remains, consider further testing for centromere, RNA polymerase III and U3-RNP, PM/Scl, or Th/To antibodies.
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Progressive Systemic Sclerosis (PSS), is a chronic systemic rheumatic disease that can effect many organ systems including the skin, the GI tract, the heart, lungs and kidneys. It occurs more commonly in females and its onset most frequently in the ages from 20 to 50 years. Sera (=plural of serum) from people with PSS contain several autoantibodies to different nuclear antigens including Scl-70, Sm and centromere antigens. Antibody to Scl-70 (topoisomerase I) is present in around 20% of patients with scleroderma, particularly those patients with a more progressive form of the disease. Scl-70 is difficult to detect by immunofluorescent studies where it gives fine speckles within the nucleus. Scl-70 antigen is present in the ENAscreen. Samples positive for the ENAscreen but negative for Ro, La, RNP, Sm or the centromere antigen will automatically be tested for Scl-70. However, since many Scl-70 sera are also positive for other ENAs (Ro52or RNP) it is best to specifically request Scl70 or give scleroderma as clinical details where appropriate.
Understanding Elevated Scl-70 Antibodies: A Comprehensive Guide
Quick Summary
An elevated Antiscleroderma-70 (Scl-70) antibody level may indicate systemic sclerosis (scleroderma) or other autoimmune conditions. This guide explains your test results, potential implications, and next steps for proper medical care.
Primary Concern: Possible systemic sclerosis or related autoimmune condition
What Does an Elevated Antiscleroderma-70 Antibody Result Mean?
The presence of Scl-70 antibodies is most commonly associated with systemic sclerosis, a chronic autoimmune disease characterized by the abnormal growth of connective tissue. Systemic sclerosis can affect the skin and internal organs, leading to a range of symptoms and potential complications. While the Scl-70 antibody is most commonly linked to this condition, an elevated level does not necessarily confirm a diagnosis of systemic sclerosis. Instead, it suggests that your body may be experiencing an autoimmune response, and further evaluation is typically needed.
Possible Diagnoses
→ Systemic Sclerosis (Scleroderma): Scl-70 antibodies are specifically associated with diffuse cutaneous systemic sclerosis, a more severe form of scleroderma that can involve widespread skin thickening as well as organ involvement (such as the lungs, kidneys, and heart).
→ Other Autoimmune Conditions: Although less common, Scl-70 antibodies can sometimes be present in other autoimmune diseases or mixed connective tissue diseases, which share some symptoms with systemic sclerosis but may have a different prognosis and treatment approach.
Symptoms of Systemic Sclerosis
If systemic sclerosis is suspected, the symptoms can vary widely, but may include:
- Skin thickening and hardening (usually starting in the fingers, hands, and face)
- Joint pain and stiffness
- Raynaud's phenomenon (a condition where the fingers and toes turn white or blue in response to cold or stress)
- Gastrointestinal issues, such as acid reflux and difficulty swallowing
- Shortness of breath (if the lungs are involved)
- Kidney problems or elevated blood pressure (if the kidneys are affected)
The severity and combination of symptoms can vary from person to person, and some people with systemic sclerosis have only limited skin involvement and fewer systemic symptoms.
Treatment Options
While there is no cure for systemic sclerosis, treatment focuses on managing symptoms, slowing disease progression, and improving quality of life. Treatment plans are typically personalized based on the organs involved and the severity of symptoms.
Medications:
- Immunosuppressants
- Corticosteroids (used cautiously)
- Vasodilators for Raynaud's phenomenon
- Antifibrotic agents for lung involvement
Physical and Occupational Therapy:
- Stretching and mobility exercises
- Joint protection techniques
- Adaptive equipment training
Lifestyle Modifications:
- Avoiding cold exposure and stress
- Dietary modifications for gastrointestinal symptoms
- Regular exercise as tolerated
- Smoking cessation if applicable
Next Steps
Immediate Actions
Additional Testing May Include
- Comprehensive blood work
- Chest X-ray or CT scan
- Pulmonary function tests
- Skin biopsy if needed
Support Resources
Professional Organizations:
- Scleroderma Foundation: www.scleroderma.org
- National Organization for Rare Disorders (NORD): www.rarediseases.org
- Arthritis Foundation: www.arthritis.org
Support Groups
- Local scleroderma support groups (check with Scleroderma Foundation)
- Online communities and forums
- Hospital-based support programs
References:
- American College of Rheumatology Guidelines for Systemic Sclerosis
- UpToDate: "Clinical manifestations and diagnosis of systemic sclerosis (scleroderma) in adults"
- Rheumatology Network: "Diagnosis and Management of Systemic Sclerosis"
- Laboratory Corporation of America (LabCorp) Reference Ranges
Note: This guide is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider for personalized medical guidance.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
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To learn more about Healthmatters Pro, please refer to the professional page.
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