Anti-Tissue Transglutaminase IgG (tTG IgG)

Serum

Optimal Result: 0 - 6.9 U/mL.

1018 Celiac Profile - Serum Genova Diagnostics

From Healthmatters.io Team

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Anti-Tissue Transglutaminase IgG (tTG IgG): What Does It Mean?

The Anti-Tissue Transglutaminase IgG (tTG IgG) marker is a key component of celiac disease testing. It measures antibodies produced by the immune system in response to tissue transglutaminase (tTG), an enzyme found in the lining of the small intestine. When individuals with celiac disease consume gluten—a protein in wheat, barley, and rye—their immune system mistakenly targets tTG, leading to the production of tTG antibodies, inflammation, and damage to the intestinal lining.

Why Is tTG IgG Important?

While the IgA version of tTG (tTG IgA) is the primary marker for celiac disease, tTG IgG is crucial for individuals with IgA deficiency, a condition where the body produces insufficient Immunoglobulin A. Since IgA deficiency occurs in about 1 in 500 people, testing tTG IgG ensures accurate results even when tTG IgA is unreliable. Elevated tTG IgG levels may suggest celiac disease or an immune reaction to gluten.

What Do Elevated tTG IgG Levels Mean?

If your tTG IgG levels are elevated, it may indicate:

Celiac Disease: Your immune system is reacting to gluten, causing damage to the intestines.
Non-Celiac Gluten Sensitivity: In some cases, elevated IgG antibodies may occur without full-blown celiac disease.
False Positives: Elevated tTG IgG can occasionally result from other conditions, such as liver disease, infections, or autoimmune disorders.

Next Steps

An elevated tTG IgG result should be interpreted alongside other markers (like deamidated gliadin peptide IgG) and clinical findings. Your healthcare provider may recommend further testing, such as an intestinal biopsy or a gluten-free diet trial, to confirm celiac disease.

Key Takeaway

The tTG IgG marker is vital for detecting gluten-related disorders, particularly in individuals with IgA deficiency. If elevated, it points to a potential immune response to gluten and warrants further evaluation to understand its cause and ensure proper management.

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Anti-Tissue Transglutaminase IgG (tTG IgG)

Anti-Tissue Transglutaminase IgG (tTG IgG): What Does It Mean?

Why Is tTG IgG Important?

What Do Elevated tTG IgG Levels Mean?

Next Steps

Key Takeaway

All Your Lab Results. One Simple Dashboard.

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
One Simple Dashboard.

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