Anti-Deamidated Gliadin IgG (DGP IgG)

Serum

Optimal Result: 0 - 6.9 U/mL.

1018 Celiac Profile - Serum Genova Diagnostics

From Healthmatters.io Team

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Anti-Deamidated Gliadin IgG (DGP IgG): What You Need to Know

The Anti-Deamidated Gliadin IgG (DGP IgG) marker is an important antibody test used to detect celiac disease and gluten-related disorders, particularly in individuals with IgA deficiency or unclear test results. It measures the immune system's response to deamidated gliadin peptides (DGP), which are modified fragments of gluten that trigger a stronger immune reaction in people sensitive to gluten.

Why Is DGP IgG Important?

While Anti-Tissue Transglutaminase IgA (tTG IgA) is the primary test for celiac disease, it may not be reliable in people with low IgA levels. In these cases, DGP IgG serves as a highly sensitive and specific marker to identify an abnormal immune response to gluten. Elevated DGP IgG levels indicate that your immune system is reacting to gluten proteins, which can lead to intestinal damage if you have celiac disease.

What Do Elevated DGP IgG Levels Mean?

Celiac Disease: Elevated DGP IgG suggests an immune reaction to gluten, particularly in those with IgA deficiency or uncertain results from other tests.
Gluten Sensitivity: Some individuals may show elevated DGP IgG without full celiac disease, indicating non-celiac gluten sensitivity.
False Positives: Rarely, elevated levels may occur due to other inflammatory or immune-related conditions.

Next Steps

If your DGP IgG levels are elevated, it’s important to consult with your healthcare provider. Additional tests, such as anti-tTG antibodies, genetic testing (HLA-DQ2/DQ8), or an intestinal biopsy, may be needed to confirm a diagnosis of celiac disease. Removing gluten from your diet under medical supervision can help resolve symptoms and prevent long-term complications.

Key Takeaway

The DGP IgG marker is especially valuable for diagnosing gluten-related disorders in individuals with IgA deficiency or inconclusive results. Elevated DGP IgG indicates a likely immune response to gluten and warrants further evaluation to confirm celiac disease and guide appropriate dietary changes.

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Anti-Deamidated Gliadin IgG (DGP IgG)

Anti-Deamidated Gliadin IgG (DGP IgG): What You Need to Know

Why Is DGP IgG Important?

What Do Elevated DGP IgG Levels Mean?

Next Steps

Key Takeaway

All Your Lab Results. One Simple Dashboard.

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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We implement proven measures to keep your data safe.

All Your Lab Results.
One Simple Dashboard.

All Your Lab Results.
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