Lipopolysaccharides (LPS) IgM

Lipopolysaccharides (LPS) is the compound in the membranes of harmful bacteria that trigger inflammation. Immune cells in the mucosal lining do not interact with LPS unless the walls are breached due to leaky gut. Upon exposure, the immune system produces antibodies to LPS, another marker we can measure to identify leaky gut. LPS antibodies also signify gut flora dysbiosis, or the overgrowth of harmful bacteria in the digestive tract. When we see LPS antibodies in the bloodstream we know it is causing inflammation throughout the body and may have breached the blood-brain barrier, causing inflammation in the brain.

Lipopolysaccharides (LPS) are endotoxins from gram-negative bacteria in the gut. The LPS protects gram-negative bacteria from gram-positive bacteria. When gram-negative bacterium dies it releases its LPS, which travels through the epithelial cells of the intestinal barrier and finds its way into the blood stream.