EARLY SJOGRENS SYNDROME PROFILE

CARBONIC ANHYDRASE VI (CA VI) IGG ANTIBODIES

A healthy result should fall into the range 0 - 20 EU/ml.

The novel antibodies salivary gland protein 1 (SP-1), carbonic anhydrase 6 (CA VI) and parotid secretory protein (PSP) have shown to be present in animal models for Sjogren's syndrome (SS) and patients with the disease. The antibodies SP-1, CA VI and PSP occurred earlier in the course of the disease than antibodies to Ro or La. These antibodies were found in 45% of patients meeting the criteria for SS who lacked antibodies to Ro or La. Furthermore, in patients with idiopathic xerostomia and xerophthalmia for less than 2 years, 76% had antibodies to SP-1 and/or CA VI while only 31% had antibodies to Ro or La. Antibodies to SP-1, CA VI and PSP may be useful markers for identifying patients with SS at early stages of the disease or those that lack antibodies to either Ro or La. The presence of the antibodies to SP-1, CA VI and PSP should be correlated with clinical (dry mouth, dry eyes), serological (Ro, La,
ANA, RF) and histological (positive lymphocytic focus scores) findings in establishing a definitive diagnosis for SS.

References:
- Shen, L. et al. (2010). A role of lymphotoxin in primary sjogren's syndrome. J Immunol; 185: 6355-6363. [L]
- Shen, L. et al. (2012). Novel autoantibodies in Sjogren's syndrome. Clinical Immunology; 145, 251-255. [L]

CARBONIC ANHYDRASE VI (CA VI) IGG ANTIBODIES result calculator

insert the value from you CARBONIC ANHYDRASE VI (CA VI) IGG ANTIBODIES test result.

What does it mean if your CARBONIC ANHYDRASE VI (CA VI) IGG ANTIBODIES result is too high?

Sjögren’s can be challenging to recognize or diagnose because symptoms of Sjögren’s may mimic those of menopause, drug side effects, or medical conditions such as lupus, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, and multiple sclerosis and thus makes receiving a prompt diagnosis difficult.

The diagnosis of Sjögren’s syndrome requires demonstration of an autoimmune disease that is adversely affecting the function of the glands that produce tears and saliva. Dry eyes and dry mouth are the most common symptoms. Assessments by a rheumatologist, ophthalmologist, and a dentist or oral medicine specialist are usually needed to search for key elements of the disease. Key elements may include an inadequate tear film, decreased saliva production, salivary gland inflammation, and an underlying autoimmune process. A careful evaluation is needed to exclude other potential causes of dryness of the eyes and of the mouth.

Although there is no cure for Sjögren syndrome, many treatments are available to minimize symptoms and reduce the risk of complications. Pharmacological treatments include lubricating eye drops, autologous serum eye drops and other prescription agents, punctal plugs, lubricating mouthwashes, mouth rinses to help remineralize damaged teeth, pilocarpine, cevimeline, and hydroxychloroquine. In more severe cases, immune-modulating treatments such as high-dose steroids, intravenous immunoglobulin, mycophenolate, or rituximab may be used. Treatment is highly individualized, and most pharmacological therapies are not FDA approved specifically for Sjögren syndrome. Lifestyle measures like using humidifiers and consuming an anti-inflammatory diet also play an important role in the management of the syndrome.

References:

- https://www.sjogrens.org/understanding-sjogrens/treatment
- https://www.sjogrens.org/understanding-sjogrens/diagnosis
- https://www.hopkinssjogrens.org/disease-information/diagnosis-sjogrens-syndrome/

WE SUPPORT 1000+ BIOMARKERS INCLUDING BIOMARKERS FROM YOUR FAVOURITE LABS

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted.
Healthmatters.io customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."

Healthmatters.io thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."

Healthmatters.io thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."



Pricing
Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.