Optimal Result: 0 - 9.3 mmol/mol creatinine.

Succinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body. Succinic acid is a key intermediate of both the Kreb’s cycle and the electron transport chain that generates adenosine triphosphate (ATP), the currency for most of the body’s energy transactions.

Succinate is produced from bacterial degradation of unabsorbed glutamine and is a metabolite of alpha-ketogluturate, as well as methionine, valine & leucine; precursor of fumaric acid; also formed from bacterial action on glutamine.

What does it mean if your Succinic result is too low?

Low levels may indicate the need for leucine/isoleucine supplementation.

What does it mean if your Succinic result is too high?

The most common cause of elevated succinic acid is exposure to toxic chemicals which impairs mitochondria function.

Succinic acid is metabolized by the mitochondrial enzyme succinic dehydrogenase, which is significant in that it is both a Krebs cycle enzyme and a component- complex 2-of the mitochondrial electron transport chain, making this metabolite a marker of mitochondrial complex 2 as well as Krebs cycle dysfunction.

A sampling of toxic chemicals that have been associated with mitochondrial dysfunction include:

- glyphosate,

- 2, 4-dichlorophenoxyacetic acid (2, 4-D),

- organophosphate pesticides,

- mercury,

- and lead. Approximately

95% of elevated succinic acid results are associated with toxic chemical exposure.

Other Krebs cycle markers may also be elevated when severe chemical toxicity is present. In general, the severity of the chemical toxicity is correlated with higher values of succinic acid.

Less common causes of elevated succinic acid are mitochondrial mutations which may be due to mutations in the nuclear or the mitochondrial DNA for mitochondrial proteins such as Kearns -Sayres disorder. Succinic acid is a metabolite of gamma aminobutyric acid (GABA) so supplementation with GABA may also increase succinic acid.

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Trust us to examine your lab results, guiding you towards improved health.

Use promo code to save 10% off any plan.

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.